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Structure-based discovery of small molecule inhibitors of the autocatalytic proliferation of α-synuclein aggregates
Sean Chia, Z. Faidon Brotzakis, Robert I. Horne, Andrea Possenti, Benedetta Mannini, Rodrigo Cataldi, Magdalena Nowinska, Roxine Staats, Sara Linse, Tuomas P. J. Knowles, Johnny Habchi, Michele Vendruscolo
doi: https://doi.org/10.1101/2021.12.05.471256
Sean Chia
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
Z. Faidon Brotzakis
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
Robert I. Horne
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
Andrea Possenti
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
Benedetta Mannini
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
Rodrigo Cataldi
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
Magdalena Nowinska
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
Roxine Staats
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
Sara Linse
2Department of Biochemistry & Structural Biology, Center for Molecular Protein Science, Lund University, 221 00 Lund, Sweden
Tuomas P. J. Knowles
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
3Department of Physics, Cavendish Laboratory, Cambridge CB3 0HE, UK
Johnny Habchi
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
Michele Vendruscolo
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK

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Posted December 05, 2021.
Structure-based discovery of small molecule inhibitors of the autocatalytic proliferation of α-synuclein aggregates
Sean Chia, Z. Faidon Brotzakis, Robert I. Horne, Andrea Possenti, Benedetta Mannini, Rodrigo Cataldi, Magdalena Nowinska, Roxine Staats, Sara Linse, Tuomas P. J. Knowles, Johnny Habchi, Michele Vendruscolo
bioRxiv 2021.12.05.471256; doi: https://doi.org/10.1101/2021.12.05.471256
Structure-based discovery of small molecule inhibitors of the autocatalytic proliferation of α-synuclein aggregates
Sean Chia, Z. Faidon Brotzakis, Robert I. Horne, Andrea Possenti, Benedetta Mannini, Rodrigo Cataldi, Magdalena Nowinska, Roxine Staats, Sara Linse, Tuomas P. J. Knowles, Johnny Habchi, Michele Vendruscolo
bioRxiv 2021.12.05.471256; doi: https://doi.org/10.1101/2021.12.05.471256
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