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Human neural networks with sparse TDP-43 pathology reveal NPTX2 misregulation in ALS/FTLD
View ORCID ProfileMarian Hruska-Plochan, Katharina M. Betz, View ORCID ProfileSilvia Ronchi, View ORCID ProfileVera I. Wiersma, Zuzanna Maniecka, Eva-Maria Hock, Florent Laferriere, Sonu Sahadevan, Vanessa Hoop, View ORCID ProfileIgor Delvendahl, Martina Panatta, Alexander van der Bourg, View ORCID ProfileDasa Bohaciakova, View ORCID ProfileKarl Frontzek, View ORCID ProfileAdriano Aguzzi, View ORCID ProfileTammaryn Lashley, View ORCID ProfileMark D. Robinson, Theofanis Karayannis, Martin Mueller, View ORCID ProfileAndreas Hierlemann, View ORCID ProfileMagdalini Polymenidou
doi: https://doi.org/10.1101/2021.12.08.471089
Marian Hruska-Plochan
1Department of Quantitative Biomedicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Katharina M. Betz
1Department of Quantitative Biomedicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
2Department of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
3SIB Swiss Institute of Bioinformatics, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Silvia Ronchi
4Department of Biosystems Science and Engineering, ETH Zürich, Mattenstrasse 26, 4058 Basel, Switzerland
Vera I. Wiersma
1Department of Quantitative Biomedicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Zuzanna Maniecka
1Department of Quantitative Biomedicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Eva-Maria Hock
1Department of Quantitative Biomedicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Florent Laferriere
1Department of Quantitative Biomedicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Sonu Sahadevan
1Department of Quantitative Biomedicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Vanessa Hoop
2Department of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Igor Delvendahl
2Department of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Martina Panatta
1Department of Quantitative Biomedicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Alexander van der Bourg
5Brain Research Institute, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Dasa Bohaciakova
7Department of Histology and Embryology, Faculty of Medicine, Masaryk University Brno, Kamenice 3, 62500, Brno, Czech Republic
Karl Frontzek
6Institute of Neuropathology, University of Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
Adriano Aguzzi
6Institute of Neuropathology, University of Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
Tammaryn Lashley
8Queen Square Brain Bank for Neurological diseases, Department of Movement Disorders, UCL Institute of Neurology, London, WC1N 1PJ, UK
9Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
Mark D. Robinson
2Department of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
3SIB Swiss Institute of Bioinformatics, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Theofanis Karayannis
5Brain Research Institute, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Martin Mueller
2Department of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Andreas Hierlemann
4Department of Biosystems Science and Engineering, ETH Zürich, Mattenstrasse 26, 4058 Basel, Switzerland
Magdalini Polymenidou
1Department of Quantitative Biomedicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Article usage
Posted December 09, 2021.
Human neural networks with sparse TDP-43 pathology reveal NPTX2 misregulation in ALS/FTLD
Marian Hruska-Plochan, Katharina M. Betz, Silvia Ronchi, Vera I. Wiersma, Zuzanna Maniecka, Eva-Maria Hock, Florent Laferriere, Sonu Sahadevan, Vanessa Hoop, Igor Delvendahl, Martina Panatta, Alexander van der Bourg, Dasa Bohaciakova, Karl Frontzek, Adriano Aguzzi, Tammaryn Lashley, Mark D. Robinson, Theofanis Karayannis, Martin Mueller, Andreas Hierlemann, Magdalini Polymenidou
bioRxiv 2021.12.08.471089; doi: https://doi.org/10.1101/2021.12.08.471089
Human neural networks with sparse TDP-43 pathology reveal NPTX2 misregulation in ALS/FTLD
Marian Hruska-Plochan, Katharina M. Betz, Silvia Ronchi, Vera I. Wiersma, Zuzanna Maniecka, Eva-Maria Hock, Florent Laferriere, Sonu Sahadevan, Vanessa Hoop, Igor Delvendahl, Martina Panatta, Alexander van der Bourg, Dasa Bohaciakova, Karl Frontzek, Adriano Aguzzi, Tammaryn Lashley, Mark D. Robinson, Theofanis Karayannis, Martin Mueller, Andreas Hierlemann, Magdalini Polymenidou
bioRxiv 2021.12.08.471089; doi: https://doi.org/10.1101/2021.12.08.471089
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