Structural models of SARS-CoV-2 Omicron variant in complex with ACE2 receptor or antibodies suggest altered binding interfaces

Joseph H. Lubin; Christopher Markosian; D. Balamurugan; Renata Pasqualini; Wadih Arap; Stephen K. Burley; Sagar D. Khare

doi:10.1101/2021.12.12.472313

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Structural models of SARS-CoV-2 Omicron variant in complex with ACE2 receptor or antibodies suggest altered binding interfaces

Joseph H. Lubin, Christopher Markosian, D. Balamurugan, Renata Pasqualini, Wadih Arap, Stephen K. Burley, Sagar D. Khare

doi: https://doi.org/10.1101/2021.12.12.472313

Joseph H. Lubin

1Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854

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Christopher Markosian

2Rutgers Cancer Institute of New Jersey, Newark, NJ 07101

3Division of Cancer Biology, Department of Radiation Oncology, Rutgers New Jersey Medical School, Newark, NJ 07103

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D. Balamurugan

4Office of Advanced Research Computing, Rutgers, The State University of New Jersey, Piscataway, NJ 08854

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Renata Pasqualini

2Rutgers Cancer Institute of New Jersey, Newark, NJ 07101

3Division of Cancer Biology, Department of Radiation Oncology, Rutgers New Jersey Medical School, Newark, NJ 07103

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Wadih Arap

2Rutgers Cancer Institute of New Jersey, Newark, NJ 07101

5Division of Hematology/Oncology, Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103

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Stephen K. Burley

1Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854

6RCSB Protein Data Bank, Rutgers, The State University of New Jersey, Piscataway, NJ 08854

7RCSB Protein Data Bank, San Diego Supercomputer Center and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92067

8Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901

9Institute for Quantitative Biomedicine, Rutgers, The State University of New Jersey, Piscataway, NJ 08854

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Sagar D. Khare

1Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854

8Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901

9Institute for Quantitative Biomedicine, Rutgers, The State University of New Jersey, Piscataway, NJ 08854

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For correspondence: khare@chem.rutgers.edu

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Posted December 13, 2021.

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Structural models of SARS-CoV-2 Omicron variant in complex with ACE2 receptor or antibodies suggest altered binding interfaces

Joseph H. Lubin, Christopher Markosian, D. Balamurugan, Renata Pasqualini, Wadih Arap, Stephen K. Burley, Sagar D. Khare

bioRxiv 2021.12.12.472313; doi: https://doi.org/10.1101/2021.12.12.472313

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Structural models of SARS-CoV-2 Omicron variant in complex with ACE2 receptor or antibodies suggest altered binding interfaces

Joseph H. Lubin, Christopher Markosian, D. Balamurugan, Renata Pasqualini, Wadih Arap, Stephen K. Burley, Sagar D. Khare

bioRxiv 2021.12.12.472313; doi: https://doi.org/10.1101/2021.12.12.472313

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