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SARS-CoV-2 T cell responses are expected to remain robust against Omicron

View ORCID ProfileSyed Faraz Ahmed, View ORCID ProfileAhmed Abdul Quadeer, View ORCID ProfileMatthew R. McKay
doi: https://doi.org/10.1101/2021.12.12.472315
Syed Faraz Ahmed
1Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China
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Ahmed Abdul Quadeer
1Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China
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  • For correspondence: matthew.mckay@unimelb.edu.au eeaaquadeer@ust.hk
Matthew R. McKay
3Department of Electrical and Electronic Engineering, University of Melbourne, Melbourne, Victoria, Australia
4Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia
1Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China
2Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China
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  • For correspondence: matthew.mckay@unimelb.edu.au eeaaquadeer@ust.hk
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ABSTRACT

Omicron, the most recent SARS-CoV-2 variant of concern (VOC), harbours multiple mutations in the spike protein that were not observed in previous VOCs. Initial studies suggest Omicron to substantially reduce the neutralizing capability of antibodies induced from vaccines and previous infection. However, its effect on T cell responses remains to be determined. Here, we assess the effect of Omicron mutations on known T cell epitopes and report data suggesting T cell responses to remain broadly robust against this new variant.

Competing Interest Statement

The authors have filed for patent protection for various applications of SARS-CoV-2 T cell epitopes.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted December 14, 2021.
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SARS-CoV-2 T cell responses are expected to remain robust against Omicron
Syed Faraz Ahmed, Ahmed Abdul Quadeer, Matthew R. McKay
bioRxiv 2021.12.12.472315; doi: https://doi.org/10.1101/2021.12.12.472315
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SARS-CoV-2 T cell responses are expected to remain robust against Omicron
Syed Faraz Ahmed, Ahmed Abdul Quadeer, Matthew R. McKay
bioRxiv 2021.12.12.472315; doi: https://doi.org/10.1101/2021.12.12.472315

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