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PIKfyve inhibition reveals a novel role for Inpp4b in the regulation of PtdIns(3)P and lysosome dynamics

Golam T. Saffi, Emily M. Mangialardi, View ORCID ProfileJean Vacher, View ORCID ProfileRoberto J. Botelho, View ORCID ProfileLeonardo Salmena
doi: https://doi.org/10.1101/2021.12.13.472440
Golam T. Saffi
1Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada
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Emily M. Mangialardi
1Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada
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Jean Vacher
2Institut de Recherches Cliniques de Montréal (IRCM), Département de Médecine, Université de Montréal, Montréal, Québec, Canada
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Roberto J. Botelho
3Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada
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Leonardo Salmena
1Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada
4Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
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  • ORCID record for Leonardo Salmena
  • For correspondence: leonardo.salmena@utoronto.ca
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Article Information

doi 
https://doi.org/10.1101/2021.12.13.472440
History 
  • December 14, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Golam T. Saffi1,
  2. Emily M. Mangialardi1,
  3. Jean Vacher2,
  4. Roberto J. Botelho3 and
  5. Leonardo Salmena1,4,‡
  1. 1Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada
  2. 2Institut de Recherches Cliniques de Montréal (IRCM), Département de Médecine, Université de Montréal, Montréal, Québec, Canada
  3. 3Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada
  4. 4Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
  1. ↵‡Correspondence to Leonardo Salmena: leonardo.salmena{at}utoronto.ca
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Posted December 14, 2021.
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PIKfyve inhibition reveals a novel role for Inpp4b in the regulation of PtdIns(3)P and lysosome dynamics
Golam T. Saffi, Emily M. Mangialardi, Jean Vacher, Roberto J. Botelho, Leonardo Salmena
bioRxiv 2021.12.13.472440; doi: https://doi.org/10.1101/2021.12.13.472440
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PIKfyve inhibition reveals a novel role for Inpp4b in the regulation of PtdIns(3)P and lysosome dynamics
Golam T. Saffi, Emily M. Mangialardi, Jean Vacher, Roberto J. Botelho, Leonardo Salmena
bioRxiv 2021.12.13.472440; doi: https://doi.org/10.1101/2021.12.13.472440

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