Metalloproteinase-dependent and TMPRSS2-independnt cell surface entry pathway of SARS-CoV-2 requires the furin-cleavage site and the S2 domain of spike protein

Mizuki Yamamoto; Jin Gohda; Ayako Kobayashi; Keiko Tomita; Youko Hirayama; Naohiko Koshikawa; Motoharu Seiki; Kentaro Semba; Tetsu Akiyama; Yasushi Kawaguchi; Jun-ichiro Inoue

doi:10.1101/2021.12.14.472513

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Metalloproteinase-dependent and TMPRSS2-independnt cell surface entry pathway of SARS-CoV-2 requires the furin-cleavage site and the S2 domain of spike protein

View ORCID ProfileMizuki Yamamoto, Jin Gohda, Ayako Kobayashi, Keiko Tomita, Youko Hirayama, Naohiko Koshikawa, Motoharu Seiki, Kentaro Semba, Tetsu Akiyama, Yasushi Kawaguchi, View ORCID ProfileJun-ichiro Inoue

doi: https://doi.org/10.1101/2021.12.14.472513

Mizuki Yamamoto

1Research Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan

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ORCID record for Mizuki Yamamoto

Jin Gohda

1Research Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan

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Ayako Kobayashi

1Research Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan

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Keiko Tomita

1Research Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan

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Youko Hirayama

1Research Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan

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Naohiko Koshikawa

2Department of Life Science and Technology, Tokyo Institute of Technology, Yokohama 226-8501 Japan

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Motoharu Seiki

3Division of Cancer Cell Research, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan

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Kentaro Semba

4Department of Life Science and Medical Bio-Science, Waseda University, Shinjuku-ku, Tokyo, 162-8480, Japan

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Tetsu Akiyama

5Laboratory of Molecular and Genetic Information, Institute for Quantitative Biosciences, The University of Tokyo, Tokyo 113-0032, Japan

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Yasushi Kawaguchi

1Research Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan

6Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan

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Jun-ichiro Inoue

7Research Platform Office, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan

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ORCID record for Jun-ichiro Inoue
For correspondence: jun-i@ims.u-tokyo.ac.jp

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Posted December 15, 2021.

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Metalloproteinase-dependent and TMPRSS2-independnt cell surface entry pathway of SARS-CoV-2 requires the furin-cleavage site and the S2 domain of spike protein

Mizuki Yamamoto, Jin Gohda, Ayako Kobayashi, Keiko Tomita, Youko Hirayama, Naohiko Koshikawa, Motoharu Seiki, Kentaro Semba, Tetsu Akiyama, Yasushi Kawaguchi, Jun-ichiro Inoue

bioRxiv 2021.12.14.472513; doi: https://doi.org/10.1101/2021.12.14.472513

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Metalloproteinase-dependent and TMPRSS2-independnt cell surface entry pathway of SARS-CoV-2 requires the furin-cleavage site and the S2 domain of spike protein

Mizuki Yamamoto, Jin Gohda, Ayako Kobayashi, Keiko Tomita, Youko Hirayama, Naohiko Koshikawa, Motoharu Seiki, Kentaro Semba, Tetsu Akiyama, Yasushi Kawaguchi, Jun-ichiro Inoue

bioRxiv 2021.12.14.472513; doi: https://doi.org/10.1101/2021.12.14.472513

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