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Islet primary cilia motility controls insulin secretion

Jung Hoon Cho, Zipeng A. Li, Lifei Zhu, Brian D. Muegge, Henry F. Roseman, Toby Utterback, Louis G. Woodhams, Philip V. Bayly, View ORCID ProfileJing W. Hughes
doi: https://doi.org/10.1101/2021.12.14.472629
Jung Hoon Cho
1Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave, Saint Louis, MO, USA
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Zipeng A. Li
1Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave, Saint Louis, MO, USA
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Lifei Zhu
1Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave, Saint Louis, MO, USA
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Brian D. Muegge
1Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave, Saint Louis, MO, USA
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Henry F. Roseman
1Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave, Saint Louis, MO, USA
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Toby Utterback
2Department of Mechanical Engineering and Materials Science, Washington University McKelvey School of Engineering, 1 Brookings Drive, Saint Louis, MO, USA
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Louis G. Woodhams
2Department of Mechanical Engineering and Materials Science, Washington University McKelvey School of Engineering, 1 Brookings Drive, Saint Louis, MO, USA
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Philip V. Bayly
2Department of Mechanical Engineering and Materials Science, Washington University McKelvey School of Engineering, 1 Brookings Drive, Saint Louis, MO, USA
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Jing W. Hughes
1Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave, Saint Louis, MO, USA
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  • ORCID record for Jing W. Hughes
  • For correspondence: jing.hughes@wustl.edu
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  • Movie S1. Beta cell cilia movement in low vs high glucose[supplements/472629_file02.mp4]
  • Movie S2. Ciliobrevin inhibits beta cell motility[supplements/472629_file03.mp4]
  • Movie S3. EHNA inhibits beta cell cilia motility[supplements/472629_file04.mp4]
  • Movie S4. AA2DG inhibits beta cell cilia motility[supplements/472629_file05.mp4]
  • Movie S5. Blebbistatin does not affect beta cell cilia motility[supplements/472629_file06.mp4]
  • Movie S6. Ciliobrevin disrupts calcium dynamics in cilia reporter beta cells[supplements/472629_file07.mp4]
  • Movie S7. Human islets with green cADDis sensors[supplements/472629_file08.avi]
  • Movie S8. Human islet cilia with siR-Tubulin[supplements/472629_file09.avi]
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Posted December 14, 2021.
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Islet primary cilia motility controls insulin secretion
Jung Hoon Cho, Zipeng A. Li, Lifei Zhu, Brian D. Muegge, Henry F. Roseman, Toby Utterback, Louis G. Woodhams, Philip V. Bayly, Jing W. Hughes
bioRxiv 2021.12.14.472629; doi: https://doi.org/10.1101/2021.12.14.472629
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Islet primary cilia motility controls insulin secretion
Jung Hoon Cho, Zipeng A. Li, Lifei Zhu, Brian D. Muegge, Henry F. Roseman, Toby Utterback, Louis G. Woodhams, Philip V. Bayly, Jing W. Hughes
bioRxiv 2021.12.14.472629; doi: https://doi.org/10.1101/2021.12.14.472629

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