Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Protein Posttranslational Signatures Identified in COVID-19 Patient Plasma

Pavan Vedula, Hsin-Yao Tang, The UPenn COVID Processing Unit, David W. Speicher, View ORCID ProfileAnna Kashina
doi: https://doi.org/10.1101/2021.12.15.472822
Pavan Vedula
1Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, 19104, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hsin-Yao Tang
2The Wistar Institute, Philadelphia, 19104, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
1Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, 19104, USA
2The Wistar Institute, Philadelphia, 19104, USA
David W. Speicher
2The Wistar Institute, Philadelphia, 19104, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anna Kashina
1Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, 19104, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Anna Kashina
  • For correspondence: akashina@upenn.edu
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious virus of the coronavirus family that causes coronavirus disease-19 (COVID-19) in humans and a number of animal species. COVID-19 has rapidly propagated in the world in the past 2 years, causing a global pandemic. Here, we performed proteomic analysis of plasma samples from COVID-19 patients compared to healthy control donors in an exploratory study to gain insights into protein-level changes in the patients caused by SARS-CoV-2 infection and to identify potential proteomic and posttranslational signatures of this disease. Our results suggest a global change in protein processing and regulation that occurs in response to SARS-CoV-2, and the existence of a posttranslational COVID-19 signature that includes an elevation in threonine phosphorylation, a change in glycosylation, and a decrease in arginylation, an emerging posttranslational modification not previously implicated in infectious disease. This study provides a resource for COVID-19 researchers and, longer term, will inform our understanding of this disease and its treatment.

Key Points

  1. Plasma from COVID-19 patients exhibits prominent protein- and peptide-level changes

  2. Proteins from COVID-19 patient plasma exhibit prominent changes in several key posttranslational modifications

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted December 16, 2021.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Protein Posttranslational Signatures Identified in COVID-19 Patient Plasma
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Protein Posttranslational Signatures Identified in COVID-19 Patient Plasma
Pavan Vedula, Hsin-Yao Tang, The UPenn COVID Processing Unit, David W. Speicher, Anna Kashina
bioRxiv 2021.12.15.472822; doi: https://doi.org/10.1101/2021.12.15.472822
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Protein Posttranslational Signatures Identified in COVID-19 Patient Plasma
Pavan Vedula, Hsin-Yao Tang, The UPenn COVID Processing Unit, David W. Speicher, Anna Kashina
bioRxiv 2021.12.15.472822; doi: https://doi.org/10.1101/2021.12.15.472822

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Biochemistry
Subject Areas
All Articles
  • Animal Behavior and Cognition (4381)
  • Biochemistry (9583)
  • Bioengineering (7089)
  • Bioinformatics (24852)
  • Biophysics (12598)
  • Cancer Biology (9952)
  • Cell Biology (14348)
  • Clinical Trials (138)
  • Developmental Biology (7945)
  • Ecology (12105)
  • Epidemiology (2067)
  • Evolutionary Biology (15985)
  • Genetics (10921)
  • Genomics (14736)
  • Immunology (9869)
  • Microbiology (23655)
  • Molecular Biology (9480)
  • Neuroscience (50843)
  • Paleontology (369)
  • Pathology (1539)
  • Pharmacology and Toxicology (2681)
  • Physiology (4013)
  • Plant Biology (8655)
  • Scientific Communication and Education (1508)
  • Synthetic Biology (2392)
  • Systems Biology (6430)
  • Zoology (1346)