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Insulin secretion deficits in a Prader-Willi syndrome β-cell model are associated with a concerted downregulation of multiple endoplasmic reticulum chaperones
Erik A. Koppes, Marie A. Johnson, James J. Moresco, Patrizia Luppi, Dale W. Lewis, Donna B. Stolz, Jolene K. Diedrich, John R. Yates III, Ronald C. Wek, Simon C. Watkins, Susanne M. Gollin, Hyun J. Park, Peter Drain, Robert D. Nicholls
doi: https://doi.org/10.1101/2021.12.16.473032
Erik A. Koppes
1Division of Genetic and Genomic Medicine, Department of Pediatrics, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA 15224
Marie A. Johnson
1Division of Genetic and Genomic Medicine, Department of Pediatrics, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA 15224
James J. Moresco
2Department of Molecular Medicine and Neurobiology, The Scripps Research Institute, La Jolla, CA 92037
Patrizia Luppi
3Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261
Dale W. Lewis
4Department of Human Genetics, University of Pittsburgh School of Public Health, Pittsburgh, PA 15261
Donna B. Stolz
3Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261
Jolene K. Diedrich
2Department of Molecular Medicine and Neurobiology, The Scripps Research Institute, La Jolla, CA 92037
John R. Yates III
2Department of Molecular Medicine and Neurobiology, The Scripps Research Institute, La Jolla, CA 92037
Ronald C. Wek
5Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202
Simon C. Watkins
3Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261
Susanne M. Gollin
4Department of Human Genetics, University of Pittsburgh School of Public Health, Pittsburgh, PA 15261
Hyun J. Park
4Department of Human Genetics, University of Pittsburgh School of Public Health, Pittsburgh, PA 15261
Peter Drain
3Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261
Robert D. Nicholls
1Division of Genetic and Genomic Medicine, Department of Pediatrics, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA 15224
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Posted June 18, 2022.
Insulin secretion deficits in a Prader-Willi syndrome β-cell model are associated with a concerted downregulation of multiple endoplasmic reticulum chaperones
Erik A. Koppes, Marie A. Johnson, James J. Moresco, Patrizia Luppi, Dale W. Lewis, Donna B. Stolz, Jolene K. Diedrich, John R. Yates III, Ronald C. Wek, Simon C. Watkins, Susanne M. Gollin, Hyun J. Park, Peter Drain, Robert D. Nicholls
bioRxiv 2021.12.16.473032; doi: https://doi.org/10.1101/2021.12.16.473032
Insulin secretion deficits in a Prader-Willi syndrome β-cell model are associated with a concerted downregulation of multiple endoplasmic reticulum chaperones
Erik A. Koppes, Marie A. Johnson, James J. Moresco, Patrizia Luppi, Dale W. Lewis, Donna B. Stolz, Jolene K. Diedrich, John R. Yates III, Ronald C. Wek, Simon C. Watkins, Susanne M. Gollin, Hyun J. Park, Peter Drain, Robert D. Nicholls
bioRxiv 2021.12.16.473032; doi: https://doi.org/10.1101/2021.12.16.473032
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