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SARS-CoV-2 Omicron spike mediated immune escape, infectivity and cell-cell fusion

Bo Meng, Isabella A.T.M Ferreira, Adam Abdullahi, Akatsuki Saito, Izumi Kimura, Daichi Yamasoba, Steven A. Kemp, Niluka Goonawardane, Guido Papa, Saman Fatihi, Surabhi Rathore, Terumasa Ikeda, Mako Toyoda, Toong Seng Tan, Jin Kuramochi, Shigeki Mitsunaga, Takamasa Ueno, Oscar J. Charles, CITIID-NIHR BioResource COVID-19 Collaboration, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Ecuador-COVID19 Consortium, Kenneth G.C. Smith, John Bradley, Jinwook Choi, Elo Madissoon, Kerstin Meyer, Petra Mlcochova, Rainer Doffinger, Sarah A. Teichmann, Leo James, Joo Hyeon Lee, Lipi Thukral, Kei Sato, View ORCID ProfileRavindra K. Gupta
doi: https://doi.org/10.1101/2021.12.17.473248
Bo Meng
1Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK
2Department of Medicine, University of Cambridge, Cambridge, UK
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Isabella A.T.M Ferreira
1Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK
2Department of Medicine, University of Cambridge, Cambridge, UK
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Adam Abdullahi
1Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK
2Department of Medicine, University of Cambridge, Cambridge, UK
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Akatsuki Saito
3Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Miyazaki 8892192, Japan
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Izumi Kimura
4Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, 1088639, Japan
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Daichi Yamasoba
5Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto 8600811, Japan
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Steven A. Kemp
1Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK
2Department of Medicine, University of Cambridge, Cambridge, UK
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Niluka Goonawardane
1Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK
2Department of Medicine, University of Cambridge, Cambridge, UK
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Guido Papa
6MRC – Laboratory of Molecular Biology, Cambridge, UK
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Saman Fatihi
7CSIR Institute of Genomics and Integrative Biology, Delhi, India
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Surabhi Rathore
7CSIR Institute of Genomics and Integrative Biology, Delhi, India
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Terumasa Ikeda
5Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto 8600811, Japan
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Mako Toyoda
8Division of Infection and Immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto 8600811, Japan
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Toong Seng Tan
9Kuramochi Clinic Interpark, Utsunomiya, Tochigi 3210114, Japan
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Jin Kuramochi
9Kuramochi Clinic Interpark, Utsunomiya, Tochigi 3210114, Japan
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Shigeki Mitsunaga
10Human Genetics Laboratory, National Institute of Genetics, Mishima, Shizuoka 4118540, Japan
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Takamasa Ueno
8Division of Infection and Immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto 8600811, Japan
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Oscar J. Charles
12Division of Infection and Immunity, UCL, London
5Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto 8600811, Japan
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Kenneth G.C. Smith
1Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK
2Department of Medicine, University of Cambridge, Cambridge, UK
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John Bradley
2Department of Medicine, University of Cambridge, Cambridge, UK
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Jinwook Choi
13Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK
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Elo Madissoon
14Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
15European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton CB10 1SD, UK
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Kerstin Meyer
14Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
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Petra Mlcochova
1Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK
2Department of Medicine, University of Cambridge, Cambridge, UK
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Rainer Doffinger
2Department of Medicine, University of Cambridge, Cambridge, UK
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Sarah A. Teichmann
14Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
16Cavendish Laboratory/Dept Physics, University of Cambridge, JJ Thomson Ave, Cambridge CB3 0HE, UK
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Leo James
3Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Miyazaki 8892192, Japan
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Joo Hyeon Lee
13Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK
17Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
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Lipi Thukral
7CSIR Institute of Genomics and Integrative Biology, Delhi, India
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Kei Sato
4Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, 1088639, Japan
18CREST, Japan Science and Technology Agency, Saitama 3220012, Japan
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  • For correspondence: rkg20@cam.ac.uk keisato@g.ecc.u-tokyo.ac.jp
Ravindra K. Gupta
1Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK
2Department of Medicine, University of Cambridge, Cambridge, UK
19Africa Health Research Institute, Durban, South Africa
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  • ORCID record for Ravindra K. Gupta
  • For correspondence: rkg20@cam.ac.uk keisato@g.ecc.u-tokyo.ac.jp
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Article Information

doi 
https://doi.org/10.1101/2021.12.17.473248
History 
  • December 22, 2021.

Article Versions

  • Version 1 (December 21, 2021 - 00:40).
  • You are currently viewing Version 2 of this article (December 22, 2021 - 15:03).
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Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Bo Meng1,2,#,
  2. Isabella A.T.M Ferreira1,2,#,
  3. Adam Abdullahi1,2,#,
  4. Akatsuki Saito3,#,
  5. Izumi Kimura4,#,
  6. Daichi Yamasoba5,#,
  7. Steven A. Kemp1,2,
  8. Niluka Goonawardane1,2,
  9. Guido Papa6,
  10. Saman Fatihi7,
  11. Surabhi Rathore7,
  12. Terumasa Ikeda5,
  13. Mako Toyoda8,
  14. Toong Seng Tan9,
  15. Jin Kuramochi9,
  16. Shigeki Mitsunaga10,
  17. Takamasa Ueno8,
  18. Oscar J. Charles12,5,
  19. CITIID-NIHR BioResource COVID-19 Collaboration,
  20. The Genotype to Phenotype Japan (G2P-Japan) Consortium,
  21. Ecuador-COVID19 Consortium,
  22. Kenneth G.C. Smith1,2,
  23. John Bradley2,
  24. Jinwook Choi13,
  25. Elo Madissoon14,15,
  26. Kerstin Meyer14,
  27. Petra Mlcochova1,2,
  28. Rainer Doffinger2,
  29. Sarah A. Teichmann14,16,
  30. Leo James3,
  31. Joo Hyeon Lee13,17,
  32. Lipi Thukral7,
  33. Kei Sato4,18,* and
  34. Ravindra K. Gupta1,2,19,*
  1. 1Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK
  2. 2Department of Medicine, University of Cambridge, Cambridge, UK
  3. 3Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Miyazaki 8892192, Japan
  4. 4Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, 1088639, Japan
  5. 5Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto 8600811, Japan
  6. 6MRC – Laboratory of Molecular Biology, Cambridge, UK
  7. 7CSIR Institute of Genomics and Integrative Biology, Delhi, India
  8. 8Division of Infection and Immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto 8600811, Japan
  9. 9Kuramochi Clinic Interpark, Utsunomiya, Tochigi 3210114, Japan
  10. 10Human Genetics Laboratory, National Institute of Genetics, Mishima, Shizuoka 4118540, Japan
  11. 11Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto 6068507, Japan
  12. 12Division of Infection and Immunity, UCL, London
  13. 13Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK
  14. 14Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
  15. 15European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton CB10 1SD, UK
  16. 16Cavendish Laboratory/Dept Physics, University of Cambridge, JJ Thomson Ave, Cambridge CB3 0HE, UK
  17. 17Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
  18. 18CREST, Japan Science and Technology Agency, Saitama 3220012, Japan
  19. 19Africa Health Research Institute, Durban, South Africa
  1. ↵*Address for correspondence: rkg20{at}cam.ac.uk; keisato{at}g.ecc.u-tokyo.ac.jp
  1. ↵# Equal contribution.

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SARS-CoV-2 Omicron spike mediated immune escape, infectivity and cell-cell fusion
Bo Meng, Isabella A.T.M Ferreira, Adam Abdullahi, Akatsuki Saito, Izumi Kimura, Daichi Yamasoba, Steven A. Kemp, Niluka Goonawardane, Guido Papa, Saman Fatihi, Surabhi Rathore, Terumasa Ikeda, Mako Toyoda, Toong Seng Tan, Jin Kuramochi, Shigeki Mitsunaga, Takamasa Ueno, Oscar J. Charles, CITIID-NIHR BioResource COVID-19 Collaboration, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Ecuador-COVID19 Consortium, Kenneth G.C. Smith, John Bradley, Jinwook Choi, Elo Madissoon, Kerstin Meyer, Petra Mlcochova, Rainer Doffinger, Sarah A. Teichmann, Leo James, Joo Hyeon Lee, Lipi Thukral, Kei Sato, Ravindra K. Gupta
bioRxiv 2021.12.17.473248; doi: https://doi.org/10.1101/2021.12.17.473248
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SARS-CoV-2 Omicron spike mediated immune escape, infectivity and cell-cell fusion
Bo Meng, Isabella A.T.M Ferreira, Adam Abdullahi, Akatsuki Saito, Izumi Kimura, Daichi Yamasoba, Steven A. Kemp, Niluka Goonawardane, Guido Papa, Saman Fatihi, Surabhi Rathore, Terumasa Ikeda, Mako Toyoda, Toong Seng Tan, Jin Kuramochi, Shigeki Mitsunaga, Takamasa Ueno, Oscar J. Charles, CITIID-NIHR BioResource COVID-19 Collaboration, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Ecuador-COVID19 Consortium, Kenneth G.C. Smith, John Bradley, Jinwook Choi, Elo Madissoon, Kerstin Meyer, Petra Mlcochova, Rainer Doffinger, Sarah A. Teichmann, Leo James, Joo Hyeon Lee, Lipi Thukral, Kei Sato, Ravindra K. Gupta
bioRxiv 2021.12.17.473248; doi: https://doi.org/10.1101/2021.12.17.473248

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