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SARS-CoV-2 Omicron spike mediated immune escape and tropism shift
Bo Meng, Isabella A.T.M Ferreira, Adam Abdullahi, Niluka Goonawardane, Akatsuki Saito, Izumi Kimura, Daichi Yamasoba, Pehuén Perera Gerba, Saman Fatihi, Surabhi Rathore, Samantha K Zepeda, Guido Papa, Steven A. Kemp, Terumasa Ikeda, Mako Toyoda, Toong Seng Tan, Jin Kuramochi, Shigeki Mitsunaga, Takamasa Ueno, Kotaro Shirakawa, Akifumi Takaori-Kondo, Teresa Brevini, Donna L. Mallery, Oscar J. Charles, CITIID-NIHR BioResource COVID-19 Collaboration, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Ecuador-COVID19 Consortium, John E Bowen, Anshu Joshi, Alexandra C. Walls, Laurelle Jackson, Sandile Cele, Darren Martin, Kenneth G.C. Smith, John Bradley, John A. G. Briggs, Jinwook Choi, Elo Madissoon, Kerstin Meyer, Petra Mlcochova, Lourdes Ceron-Gutierrez, Rainer Doffinger, Sarah Teichmann, Matteo Pizzuto, Anna de Marco, Davide Corti, Alex Sigal, Leo James, David Veesler, Myra Hosmillo, Joo Hyeon Lee, Fotios Sampaziotis, Ian G Goodfellow, Nicholas J. Matheson, Lipi Thukral, Kei Sato, View ORCID ProfileRavindra K. Gupta
doi: https://doi.org/10.1101/2021.12.17.473248
Bo Meng
1Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK
2Department of Medicine, University of Cambridge, Cambridge, UK
Isabella A.T.M Ferreira
1Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK
2Department of Medicine, University of Cambridge, Cambridge, UK
Adam Abdullahi
1Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK
2Department of Medicine, University of Cambridge, Cambridge, UK
Niluka Goonawardane
1Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK
2Department of Medicine, University of Cambridge, Cambridge, UK
Akatsuki Saito
3Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Miyazaki 8892192, Japan
Izumi Kimura
4Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, 1088639, Japan
Daichi Yamasoba
5Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto 8600811, Japan
Pehuén Perera Gerba
1Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK
2Department of Medicine, University of Cambridge, Cambridge, UK
Saman Fatihi
6CSIR Institute of Genomics and Integrative Biology, Delhi, India
Surabhi Rathore
6CSIR Institute of Genomics and Integrative Biology, Delhi, India
Samantha K Zepeda
7Department of Biochemistry, University of Washington, Seattle, 98195 USA
Guido Papa
8MRC – Laboratory of Molecular Biology, Cambridge, UK
Steven A. Kemp
1Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK
2Department of Medicine, University of Cambridge, Cambridge, UK
Terumasa Ikeda
5Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto 8600811, Japan
Mako Toyoda
9Division of Infection and Immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto 8600811, Japan
Toong Seng Tan
10Kuramochi Clinic Interpark, Utsunomiya, Tochigi 3210114, Japan
Jin Kuramochi
10Kuramochi Clinic Interpark, Utsunomiya, Tochigi 3210114, Japan
Shigeki Mitsunaga
11Human Genetics Laboratory, National Institute of Genetics, Mishima, Shizuoka 4118540, Japan
Takamasa Ueno
9Division of Infection and Immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto 8600811, Japan
Kotaro Shirakawa
12Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto 6068507, Japan
Akifumi Takaori-Kondo
12Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto 6068507, Japan
Teresa Brevini
2Department of Medicine, University of Cambridge, Cambridge, UK
Donna L. Mallery
8MRC – Laboratory of Molecular Biology, Cambridge, UK
Oscar J. Charles
13Division of Infection and Immunity, UCL, London
John E Bowen
7Department of Biochemistry, University of Washington, Seattle, 98195 USA
Anshu Joshi
7Department of Biochemistry, University of Washington, Seattle, 98195 USA
Alexandra C. Walls
7Department of Biochemistry, University of Washington, Seattle, 98195 USA
23Howard Hughes Medical Institute, Seattle, WA 98195, USA
Laurelle Jackson
14Africa Health Research Institute, Durban, South Africa
Sandile Cele
14Africa Health Research Institute, Durban, South Africa
Darren Martin
15University of Cape Town, Cape Town 7701, South Africa
Kenneth G.C. Smith
1Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK
2Department of Medicine, University of Cambridge, Cambridge, UK
John Bradley
2Department of Medicine, University of Cambridge, Cambridge, UK
John A. G. Briggs
16Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
Jinwook Choi
17Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK
Elo Madissoon
18Welcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK
19European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton CB10 1SD, UK
Kerstin Meyer
18Welcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Petra Mlcochova
1Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK
2Department of Medicine, University of Cambridge, Cambridge, UK
Lourdes Ceron-Gutierrez
20Cambridge University Hospitals NHS Foundation Trust, Addenbrookes Hospital, Cambridge, UK
Rainer Doffinger
20Cambridge University Hospitals NHS Foundation Trust, Addenbrookes Hospital, Cambridge, UK
Sarah Teichmann
18Welcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK
21Cavendish Laboratory/Dept Physics, University of Cambridge, JJ Thomson Ave, Cambridge CB3 0HE, UK
Matteo Pizzuto
22Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland
Anna de Marco
22Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland
Davide Corti
22Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland
Alex Sigal
14Africa Health Research Institute, Durban, South Africa
Leo James
8MRC – Laboratory of Molecular Biology, Cambridge, UK
David Veesler
7Department of Biochemistry, University of Washington, Seattle, 98195 USA
23Howard Hughes Medical Institute, Seattle, WA 98195, USA
Myra Hosmillo
24Department of Virology, University of Cambridge, UK
Joo Hyeon Lee
17Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK
25Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
Fotios Sampaziotis
1Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK
2Department of Medicine, University of Cambridge, Cambridge, UK
17Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK
20Cambridge University Hospitals NHS Foundation Trust, Addenbrookes Hospital, Cambridge, UK
Ian G Goodfellow
26NHS Blood and Transplant, Cambridge, UK
Nicholas J. Matheson
1Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK
2Department of Medicine, University of Cambridge, Cambridge, UK
20Cambridge University Hospitals NHS Foundation Trust, Addenbrookes Hospital, Cambridge, UK
26NHS Blood and Transplant, Cambridge, UK
Lipi Thukral
6CSIR Institute of Genomics and Integrative Biology, Delhi, India
Kei Sato
4Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, 1088639, Japan
27CREST, Japan Science and Technology Agency, Saitama 3220012, Japan
Ravindra K. Gupta
1Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK
2Department of Medicine, University of Cambridge, Cambridge, UK
14Africa Health Research Institute, Durban, South Africa
26NHS Blood and Transplant, Cambridge, UK
Posted January 13, 2022.
SARS-CoV-2 Omicron spike mediated immune escape and tropism shift
Bo Meng, Isabella A.T.M Ferreira, Adam Abdullahi, Niluka Goonawardane, Akatsuki Saito, Izumi Kimura, Daichi Yamasoba, Pehuén Perera Gerba, Saman Fatihi, Surabhi Rathore, Samantha K Zepeda, Guido Papa, Steven A. Kemp, Terumasa Ikeda, Mako Toyoda, Toong Seng Tan, Jin Kuramochi, Shigeki Mitsunaga, Takamasa Ueno, Kotaro Shirakawa, Akifumi Takaori-Kondo, Teresa Brevini, Donna L. Mallery, Oscar J. Charles, CITIID-NIHR BioResource COVID-19 Collaboration, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Ecuador-COVID19 Consortium, John E Bowen, Anshu Joshi, Alexandra C. Walls, Laurelle Jackson, Sandile Cele, Darren Martin, Kenneth G.C. Smith, John Bradley, John A. G. Briggs, Jinwook Choi, Elo Madissoon, Kerstin Meyer, Petra Mlcochova, Lourdes Ceron-Gutierrez, Rainer Doffinger, Sarah Teichmann, Matteo Pizzuto, Anna de Marco, Davide Corti, Alex Sigal, Leo James, David Veesler, Myra Hosmillo, Joo Hyeon Lee, Fotios Sampaziotis, Ian G Goodfellow, Nicholas J. Matheson, Lipi Thukral, Kei Sato, Ravindra K. Gupta
bioRxiv 2021.12.17.473248; doi: https://doi.org/10.1101/2021.12.17.473248
SARS-CoV-2 Omicron spike mediated immune escape and tropism shift
Bo Meng, Isabella A.T.M Ferreira, Adam Abdullahi, Niluka Goonawardane, Akatsuki Saito, Izumi Kimura, Daichi Yamasoba, Pehuén Perera Gerba, Saman Fatihi, Surabhi Rathore, Samantha K Zepeda, Guido Papa, Steven A. Kemp, Terumasa Ikeda, Mako Toyoda, Toong Seng Tan, Jin Kuramochi, Shigeki Mitsunaga, Takamasa Ueno, Kotaro Shirakawa, Akifumi Takaori-Kondo, Teresa Brevini, Donna L. Mallery, Oscar J. Charles, CITIID-NIHR BioResource COVID-19 Collaboration, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Ecuador-COVID19 Consortium, John E Bowen, Anshu Joshi, Alexandra C. Walls, Laurelle Jackson, Sandile Cele, Darren Martin, Kenneth G.C. Smith, John Bradley, John A. G. Briggs, Jinwook Choi, Elo Madissoon, Kerstin Meyer, Petra Mlcochova, Lourdes Ceron-Gutierrez, Rainer Doffinger, Sarah Teichmann, Matteo Pizzuto, Anna de Marco, Davide Corti, Alex Sigal, Leo James, David Veesler, Myra Hosmillo, Joo Hyeon Lee, Fotios Sampaziotis, Ian G Goodfellow, Nicholas J. Matheson, Lipi Thukral, Kei Sato, Ravindra K. Gupta
bioRxiv 2021.12.17.473248; doi: https://doi.org/10.1101/2021.12.17.473248
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