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Induction of flight via midbrain projections to the cuneiform nucleus

Emmy Tsang, Camilla Orlandini, Rahul Sureka, Alvaro H. Crevenna, Emerald Perlas, Izzie Prankerd, Maria E. Masferrer, Cornelius T. Gross
doi: https://doi.org/10.1101/2021.12.21.473683
Emmy Tsang
1Epigenetics & Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Via Ramarini 32, 00015 Monterotondo (RM), Italy
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Camilla Orlandini
1Epigenetics & Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Via Ramarini 32, 00015 Monterotondo (RM), Italy
2Neurobiology Master’s Program, Sapienza University, Piazzale Aldo Moro, Rome, Italy
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Rahul Sureka
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Alvaro H. Crevenna
1Epigenetics & Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Via Ramarini 32, 00015 Monterotondo (RM), Italy
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Emerald Perlas
1Epigenetics & Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Via Ramarini 32, 00015 Monterotondo (RM), Italy
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Izzie Prankerd
1Epigenetics & Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Via Ramarini 32, 00015 Monterotondo (RM), Italy
3University of Bath, Bath, UK
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Maria E. Masferrer
1Epigenetics & Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Via Ramarini 32, 00015 Monterotondo (RM), Italy
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Cornelius T. Gross
1Epigenetics & Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Via Ramarini 32, 00015 Monterotondo (RM), Italy
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  • For correspondence: gross@embl.it
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Abstract

The dorsal periaqueductal gray is a midbrain structure implicated in the control of defensive behaviors and the processing of painful stimuli. Electrical stimulation or optogenetic activation of excitatory neurons in dorsal periaqueductal gray results in freezing or flight behavior at low or high intensity, respectively. However, the output structures that mediate these defensive behaviors remain unconfirmed. Here we carried out a targeted classification of neuron types in dorsal periaqueductal gray using multiplex in situ sequencing and then applied cell-type and projection-specific optogenetic stimulation to identify projections from dorsal periaqueductal grey to the cuneiform nucleus that promoted goal-directed flight behavior. These data confirmed that descending outputs from dorsal periaqueductal gray serve as a trigger for directed escape behavior.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted December 23, 2021.
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Induction of flight via midbrain projections to the cuneiform nucleus
Emmy Tsang, Camilla Orlandini, Rahul Sureka, Alvaro H. Crevenna, Emerald Perlas, Izzie Prankerd, Maria E. Masferrer, Cornelius T. Gross
bioRxiv 2021.12.21.473683; doi: https://doi.org/10.1101/2021.12.21.473683
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Induction of flight via midbrain projections to the cuneiform nucleus
Emmy Tsang, Camilla Orlandini, Rahul Sureka, Alvaro H. Crevenna, Emerald Perlas, Izzie Prankerd, Maria E. Masferrer, Cornelius T. Gross
bioRxiv 2021.12.21.473683; doi: https://doi.org/10.1101/2021.12.21.473683

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