Liquid-liquid phase separation facilitates the biogenesis of secretory storage granules

Anup Parchure; Meng Tian; Cierra K Boyer; Shelby C Bearrows; Kristen E Rohli; Jianchao Zhang; Bulat R Ramazanov; Yanzhuang Wang; Samuel B Stephens; Julia von Blume

doi:10.1101/2021.12.22.472607

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Liquid-liquid phase separation facilitates the biogenesis of secretory storage granules

Anup Parchure, Meng Tian, Cierra K Boyer, Shelby C Bearrows, Kristen E Rohli, Jianchao Zhang, Bulat R Ramazanov, View ORCID ProfileYanzhuang Wang, View ORCID ProfileSamuel B Stephens, Julia von Blume

doi: https://doi.org/10.1101/2021.12.22.472607

Anup Parchure

1Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA

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Meng Tian

1Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA

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Cierra K Boyer

2Fraternal Order of Eagles Diabetes Research Center, Departments of Pharmacology and Neuroscience and Internal Medicine

3Division of Endocrinology and Metabolism, University of Iowa, Iowa City, IA, USA

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Shelby C Bearrows

2Fraternal Order of Eagles Diabetes Research Center, Departments of Pharmacology and Neuroscience and Internal Medicine

3Division of Endocrinology and Metabolism, University of Iowa, Iowa City, IA, USA

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Kristen E Rohli

2Fraternal Order of Eagles Diabetes Research Center, Departments of Pharmacology and Neuroscience and Internal Medicine

3Division of Endocrinology and Metabolism, University of Iowa, Iowa City, IA, USA

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Jianchao Zhang

4Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA

5Department of Neurology, University of Michigan School of Medicine, Ann Arbor, MI, USA

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Bulat R Ramazanov

1Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA

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Yanzhuang Wang

4Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA

5Department of Neurology, University of Michigan School of Medicine, Ann Arbor, MI, USA

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ORCID record for Yanzhuang Wang

Samuel B Stephens

2Fraternal Order of Eagles Diabetes Research Center, Departments of Pharmacology and Neuroscience and Internal Medicine

3Division of Endocrinology and Metabolism, University of Iowa, Iowa City, IA, USA

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ORCID record for Samuel B Stephens

Julia von Blume

1Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA

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For correspondence: julia.vonblume@yale.edu

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Liquid-liquid phase separation facilitates the biogenesis of secretory storage granules

Anup Parchure, Meng Tian, Cierra K Boyer, Shelby C Bearrows, Kristen E Rohli, Jianchao Zhang, Bulat R Ramazanov, Yanzhuang Wang, Samuel B Stephens, Julia von Blume

bioRxiv 2021.12.22.472607; doi: https://doi.org/10.1101/2021.12.22.472607

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Liquid-liquid phase separation facilitates the biogenesis of secretory storage granules

Anup Parchure, Meng Tian, Cierra K Boyer, Shelby C Bearrows, Kristen E Rohli, Jianchao Zhang, Bulat R Ramazanov, Yanzhuang Wang, Samuel B Stephens, Julia von Blume

bioRxiv 2021.12.22.472607; doi: https://doi.org/10.1101/2021.12.22.472607

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