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In vitro evolution predicts emerging CoV-2 mutations with high affinity for ACE2 and cross-species binding

Neil Bate, Christos G Savva, Peter CE Moody, Edward A Brown, Jonathan K Ball, John WR Schwabe, View ORCID ProfileJulian E Sale, View ORCID ProfileNicholas PJ Brindle
doi: https://doi.org/10.1101/2021.12.23.473975
Neil Bate
1Department of Molecular & Cell Biology, University of Leicester, University Road, Leicester, Leicester LE1 7RH UK
2Department of Cardiovascular Sciences, University of Leicester, University Road, Leicester, Leicester LE1 7RH UK
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Christos G Savva
3Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cellular Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK
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Peter CE Moody
3Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cellular Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK
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Edward A Brown
3Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cellular Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK
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Jonathan K Ball
4School of Life Sciences, The University of Nottingham, Nottingham NG7 2UH, UK
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John WR Schwabe
3Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cellular Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK
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Julian E Sale
5Division of Protein & Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK
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  • ORCID record for Julian E Sale
Nicholas PJ Brindle
1Department of Molecular & Cell Biology, University of Leicester, University Road, Leicester, Leicester LE1 7RH UK
2Department of Cardiovascular Sciences, University of Leicester, University Road, Leicester, Leicester LE1 7RH UK
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  • ORCID record for Nicholas PJ Brindle
  • For correspondence: NPJB1@Le.ac.uk
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Article Information

doi 
https://doi.org/10.1101/2021.12.23.473975
History 
  • December 25, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Neil Bate1,2,
  2. Christos G Savva3,
  3. Peter CE Moody3,
  4. Edward A Brown3,
  5. Jonathan K Ball4,
  6. John WR Schwabe3,
  7. Julian E Sale5 and
  8. Nicholas PJ Brindle1,2,*
  1. 1Department of Molecular & Cell Biology, University of Leicester, University Road, Leicester, Leicester LE1 7RH UK
  2. 2Department of Cardiovascular Sciences, University of Leicester, University Road, Leicester, Leicester LE1 7RH UK
  3. 3Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cellular Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK
  4. 4School of Life Sciences, The University of Nottingham, Nottingham NG7 2UH, UK
  5. 5Division of Protein & Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK
  1. ↵*Corresponding author
    Nicholas PJ Brindle, Dept Molecular & Cell Biology, University of Leicester, University Road, Leicester, LE1 7RH UK, Email: NPJB1{at}Le.ac.uk, Tel: +44(0)116 229 7170
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Posted December 25, 2021.
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In vitro evolution predicts emerging CoV-2 mutations with high affinity for ACE2 and cross-species binding
Neil Bate, Christos G Savva, Peter CE Moody, Edward A Brown, Jonathan K Ball, John WR Schwabe, Julian E Sale, Nicholas PJ Brindle
bioRxiv 2021.12.23.473975; doi: https://doi.org/10.1101/2021.12.23.473975
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In vitro evolution predicts emerging CoV-2 mutations with high affinity for ACE2 and cross-species binding
Neil Bate, Christos G Savva, Peter CE Moody, Edward A Brown, Jonathan K Ball, John WR Schwabe, Julian E Sale, Nicholas PJ Brindle
bioRxiv 2021.12.23.473975; doi: https://doi.org/10.1101/2021.12.23.473975

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