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In vitro evolution predicts emerging CoV-2 mutations with high affinity for ACE2 and cross-species binding
Neil Bate, Christos G Savva, Peter CE Moody, Edward A Brown, Jonathan K Ball, John WR Schwabe, View ORCID ProfileJulian E Sale, View ORCID ProfileNicholas PJ Brindle
doi: https://doi.org/10.1101/2021.12.23.473975
Neil Bate
1Department of Molecular & Cell Biology, University of Leicester, University Road, Leicester, Leicester LE1 7RH UK
2Department of Cardiovascular Sciences, University of Leicester, University Road, Leicester, Leicester LE1 7RH UK
Christos G Savva
3Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cellular Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK
Peter CE Moody
3Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cellular Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK
Edward A Brown
3Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cellular Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK
Jonathan K Ball
4School of Life Sciences, The University of Nottingham, Nottingham NG7 2UH, UK
John WR Schwabe
3Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cellular Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK
Julian E Sale
5Division of Protein & Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK
Nicholas PJ Brindle
1Department of Molecular & Cell Biology, University of Leicester, University Road, Leicester, Leicester LE1 7RH UK
2Department of Cardiovascular Sciences, University of Leicester, University Road, Leicester, Leicester LE1 7RH UK
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Posted December 25, 2021.
In vitro evolution predicts emerging CoV-2 mutations with high affinity for ACE2 and cross-species binding
Neil Bate, Christos G Savva, Peter CE Moody, Edward A Brown, Jonathan K Ball, John WR Schwabe, Julian E Sale, Nicholas PJ Brindle
bioRxiv 2021.12.23.473975; doi: https://doi.org/10.1101/2021.12.23.473975
In vitro evolution predicts emerging CoV-2 mutations with high affinity for ACE2 and cross-species binding
Neil Bate, Christos G Savva, Peter CE Moody, Edward A Brown, Jonathan K Ball, John WR Schwabe, Julian E Sale, Nicholas PJ Brindle
bioRxiv 2021.12.23.473975; doi: https://doi.org/10.1101/2021.12.23.473975
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