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SARS-CoV-2 Omicron-B.1.1.529 Variant leads to less severe disease than Pango B and Delta variants strains in a mouse model of severe COVID-19

Eleanor G. Bentley, Adam Kirby, Parul Sharma, Anja Kipar, Daniele F. Mega, Chloe Bramwell, Rebekah Penrice-Randal, Tessa Prince, Jonathan C. Brown, Jie Zhou, Gavin R. Screaton, Wendy S. Barclay, Andrew Owen, Julian A. Hiscox, View ORCID ProfileJames P. Stewart
doi: https://doi.org/10.1101/2021.12.26.474085
Eleanor G. Bentley
1Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
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Adam Kirby
1Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
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Parul Sharma
1Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
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Anja Kipar
1Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
2Laboratory for Animal Model Pathology, Institute of Veterinary Pathology, University of Zurich, Switzerland
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Daniele F. Mega
1Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
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Chloe Bramwell
1Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
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Rebekah Penrice-Randal
1Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
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Tessa Prince
1Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
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Jonathan C. Brown
3Department of Infectious Disease, Imperial College London, London, UK
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Jie Zhou
3Department of Infectious Disease, Imperial College London, London, UK
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Gavin R. Screaton
4Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK
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Wendy S. Barclay
3Department of Infectious Disease, Imperial College London, London, UK
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Andrew Owen
5Department of Pharmacology and Therapeutics, Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, UK
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Julian A. Hiscox
1Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
6Department of Preventive Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China
7Infectious Diseases Horizontal Technology Centre (ID HTC), A*STAR, Singapore
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James P. Stewart
1Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
6Department of Preventive Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China
8Department of Infectious Disease, University of Georgia, Georgia, USA
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  • ORCID record for James P. Stewart
  • For correspondence: j.p.stewart@liv.ac.uk
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Article Information

doi 
https://doi.org/10.1101/2021.12.26.474085
History 
  • December 30, 2021.

Article Versions

  • Version 1 (December 28, 2021 - 12:56).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Eleanor G. Bentley1,
  2. Adam Kirby1,
  3. Parul Sharma1,
  4. Anja Kipar1,2,
  5. Daniele F. Mega1,
  6. Chloe Bramwell1,
  7. Rebekah Penrice-Randal1,
  8. Tessa Prince1,
  9. Jonathan C. Brown3,
  10. Jie Zhou3,
  11. Gavin R. Screaton4,
  12. Wendy S. Barclay3,
  13. Andrew Owen5,
  14. Julian A. Hiscox1,6,7 and
  15. James P. Stewart1,6,8,*
  1. 1Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
  2. 2Laboratory for Animal Model Pathology, Institute of Veterinary Pathology, University of Zurich, Switzerland
  3. 3Department of Infectious Disease, Imperial College London, London, UK
  4. 4Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK
  5. 5Department of Pharmacology and Therapeutics, Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, UK
  6. 6Department of Preventive Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China
  7. 7Infectious Diseases Horizontal Technology Centre (ID HTC), A*STAR, Singapore
  8. 8Department of Infectious Disease, University of Georgia, Georgia, USA
  1. ↵*Corresponding author: E. mail: j.p.stewart{at}liv.ac.uk;
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Posted December 30, 2021.
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SARS-CoV-2 Omicron-B.1.1.529 Variant leads to less severe disease than Pango B and Delta variants strains in a mouse model of severe COVID-19
Eleanor G. Bentley, Adam Kirby, Parul Sharma, Anja Kipar, Daniele F. Mega, Chloe Bramwell, Rebekah Penrice-Randal, Tessa Prince, Jonathan C. Brown, Jie Zhou, Gavin R. Screaton, Wendy S. Barclay, Andrew Owen, Julian A. Hiscox, James P. Stewart
bioRxiv 2021.12.26.474085; doi: https://doi.org/10.1101/2021.12.26.474085
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SARS-CoV-2 Omicron-B.1.1.529 Variant leads to less severe disease than Pango B and Delta variants strains in a mouse model of severe COVID-19
Eleanor G. Bentley, Adam Kirby, Parul Sharma, Anja Kipar, Daniele F. Mega, Chloe Bramwell, Rebekah Penrice-Randal, Tessa Prince, Jonathan C. Brown, Jie Zhou, Gavin R. Screaton, Wendy S. Barclay, Andrew Owen, Julian A. Hiscox, James P. Stewart
bioRxiv 2021.12.26.474085; doi: https://doi.org/10.1101/2021.12.26.474085

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