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SARS-CoV-2 Omicron-B.1.1.529 Variant leads to less severe disease than Pango B and Delta variants strains in a mouse model of severe COVID-19

Eleanor G. Bentley, Adam Kirby, Parul Sharma, Anja Kipar, Daniele F. Mega, Chloe Bramwell, Rebekah Penrice-Randal, Tessa Prince, Jonathan C. Brown, Jie Zhou, Gavin R. Screaton, Wendy S. Barclay, Andrew Owen, Julian A. Hiscox, View ORCID ProfileJames P. Stewart
doi: https://doi.org/10.1101/2021.12.26.474085
Eleanor G. Bentley
1Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
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Adam Kirby
1Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
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Parul Sharma
1Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
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Anja Kipar
1Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
2Laboratory for Animal Model Pathology, Institute of Veterinary Pathology, University of Zurich, Switzerland
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Daniele F. Mega
1Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
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Chloe Bramwell
1Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
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Rebekah Penrice-Randal
1Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
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Tessa Prince
1Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
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Jonathan C. Brown
3Department of Infectious Disease, Imperial College London, London, UK
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Jie Zhou
3Department of Infectious Disease, Imperial College London, London, UK
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Gavin R. Screaton
4Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK
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Wendy S. Barclay
3Department of Infectious Disease, Imperial College London, London, UK
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Andrew Owen
5Department of Pharmacology and Therapeutics, Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, UK
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Julian A. Hiscox
1Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
6Department of Preventive Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China
7Infectious Diseases Horizontal Technology Centre (ID HTC), A*STAR, Singapore
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James P. Stewart
1Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK
6Department of Preventive Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China
8Department of Infectious Disease, University of Georgia, Georgia, USA
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  • ORCID record for James P. Stewart
  • For correspondence: j.p.stewart@liv.ac.uk
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Posted December 30, 2021.
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SARS-CoV-2 Omicron-B.1.1.529 Variant leads to less severe disease than Pango B and Delta variants strains in a mouse model of severe COVID-19
Eleanor G. Bentley, Adam Kirby, Parul Sharma, Anja Kipar, Daniele F. Mega, Chloe Bramwell, Rebekah Penrice-Randal, Tessa Prince, Jonathan C. Brown, Jie Zhou, Gavin R. Screaton, Wendy S. Barclay, Andrew Owen, Julian A. Hiscox, James P. Stewart
bioRxiv 2021.12.26.474085; doi: https://doi.org/10.1101/2021.12.26.474085
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SARS-CoV-2 Omicron-B.1.1.529 Variant leads to less severe disease than Pango B and Delta variants strains in a mouse model of severe COVID-19
Eleanor G. Bentley, Adam Kirby, Parul Sharma, Anja Kipar, Daniele F. Mega, Chloe Bramwell, Rebekah Penrice-Randal, Tessa Prince, Jonathan C. Brown, Jie Zhou, Gavin R. Screaton, Wendy S. Barclay, Andrew Owen, Julian A. Hiscox, James P. Stewart
bioRxiv 2021.12.26.474085; doi: https://doi.org/10.1101/2021.12.26.474085

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