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VRK1 is required in VRK2-methylated cancers of the nervous system

Jonathan So, Nathaniel W. Mabe, Bernhard Englinger, Sydney M. Moyer, Maria C. Trissal, Joana G. Marques, Jason Kwon, Brian Shim, Eshini Panditharatna, Daeun Jeong, David Mayhew, Justin Hwang, Kimberly Stegmaier, Mariella G. Filbin, William C. Hahn
doi: https://doi.org/10.1101/2021.12.28.474386
Jonathan So
1Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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Nathaniel W. Mabe
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts
3Department of Pediatric Oncology, Dana-Farber/Boston Children’s Cancer and Blood Disorder Center and Harvard Medical School, Boston, Massachusetts
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Bernhard Englinger
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts
3Department of Pediatric Oncology, Dana-Farber/Boston Children’s Cancer and Blood Disorder Center and Harvard Medical School, Boston, Massachusetts
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Sydney M. Moyer
1Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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Maria C. Trissal
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts
3Department of Pediatric Oncology, Dana-Farber/Boston Children’s Cancer and Blood Disorder Center and Harvard Medical School, Boston, Massachusetts
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Joana G. Marques
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts
3Department of Pediatric Oncology, Dana-Farber/Boston Children’s Cancer and Blood Disorder Center and Harvard Medical School, Boston, Massachusetts
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Jason Kwon
1Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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Brian Shim
1Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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Eshini Panditharatna
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts
3Department of Pediatric Oncology, Dana-Farber/Boston Children’s Cancer and Blood Disorder Center and Harvard Medical School, Boston, Massachusetts
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Daeun Jeong
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts
3Department of Pediatric Oncology, Dana-Farber/Boston Children’s Cancer and Blood Disorder Center and Harvard Medical School, Boston, Massachusetts
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David Mayhew
1Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts
4Department of Radiation Oncology, Tufts Medical Center, Boston, Massachusetts
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Justin Hwang
5Department of Medicine, University of Minnesota-Twin Cities, Minneapolis, Minnesota
6Masonic Cancer Center, University of Minnesota-Twin Cities, Minneapolis, Minnesota
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Kimberly Stegmaier
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts
3Department of Pediatric Oncology, Dana-Farber/Boston Children’s Cancer and Blood Disorder Center and Harvard Medical School, Boston, Massachusetts
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  • For correspondence: William_Hahn@dfci.harvard.edu Mariella.Filbin@childrens.harvard.edu Kimberly_Stegmaier@dfci.harvard.edu
Mariella G. Filbin
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts
3Department of Pediatric Oncology, Dana-Farber/Boston Children’s Cancer and Blood Disorder Center and Harvard Medical School, Boston, Massachusetts
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  • For correspondence: William_Hahn@dfci.harvard.edu Mariella.Filbin@childrens.harvard.edu Kimberly_Stegmaier@dfci.harvard.edu
William C. Hahn
1Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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  • For correspondence: William_Hahn@dfci.harvard.edu Mariella.Filbin@childrens.harvard.edu Kimberly_Stegmaier@dfci.harvard.edu
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Article Information

doi 
https://doi.org/10.1101/2021.12.28.474386
History 
  • December 30, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Jonathan So1,2,⋆,
  2. Nathaniel W. Mabe2,3,⋆,
  3. Bernhard Englinger2,3,⋆,
  4. Sydney M. Moyer1,2,
  5. Maria C. Trissal2,3,
  6. Joana G. Marques2,3,
  7. Jason Kwon1,2,
  8. Brian Shim1,2,
  9. Eshini Panditharatna2,3,
  10. Daeun Jeong2,3,
  11. David Mayhew1,2,4,
  12. Justin Hwang5,6,
  13. Kimberly Stegmaier2,3,†,#,
  14. Mariella G. Filbin2,3,†,# and
  15. William C. Hahn1,2,†,#
  1. 1Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts
  2. 2Broad Institute of MIT and Harvard, Cambridge, Massachusetts
  3. 3Department of Pediatric Oncology, Dana-Farber/Boston Children’s Cancer and Blood Disorder Center and Harvard Medical School, Boston, Massachusetts
  4. 4Department of Radiation Oncology, Tufts Medical Center, Boston, Massachusetts
  5. 5Department of Medicine, University of Minnesota-Twin Cities, Minneapolis, Minnesota
  6. 6Masonic Cancer Center, University of Minnesota-Twin Cities, Minneapolis, Minnesota
  1. ↵#Corresponding Authors:
    William C. Hahn, M.D., Ph.D., 450 Brookline Avenue, Dana 1630, Boston, MA 02215 USA, 617-632-5244, William_Hahn{at}dfci.harvard.edu, Mariella G. Filbin, M.D., Ph.D., 360 Longwood Avenue, LC 6101, Boston, MA 02215 USA, 617-632-5993, Mariella.Filbin{at}childrens.harvard.edu, Kimberly Stegmaier, M.D., 450 Brookline Avenue, Dana 630D, Boston, MA 02215 USA, 617-632-4438, Kimberly_Stegmaier{at}dfci.harvard.edu
  1. ↵⋆ These authors contributed equally to this article.

  2. ↵† These senior authors contributed equally to this article.

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VRK1 is required in VRK2-methylated cancers of the nervous system
Jonathan So, Nathaniel W. Mabe, Bernhard Englinger, Sydney M. Moyer, Maria C. Trissal, Joana G. Marques, Jason Kwon, Brian Shim, Eshini Panditharatna, Daeun Jeong, David Mayhew, Justin Hwang, Kimberly Stegmaier, Mariella G. Filbin, William C. Hahn
bioRxiv 2021.12.28.474386; doi: https://doi.org/10.1101/2021.12.28.474386
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VRK1 is required in VRK2-methylated cancers of the nervous system
Jonathan So, Nathaniel W. Mabe, Bernhard Englinger, Sydney M. Moyer, Maria C. Trissal, Joana G. Marques, Jason Kwon, Brian Shim, Eshini Panditharatna, Daeun Jeong, David Mayhew, Justin Hwang, Kimberly Stegmaier, Mariella G. Filbin, William C. Hahn
bioRxiv 2021.12.28.474386; doi: https://doi.org/10.1101/2021.12.28.474386

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