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VRK1 is a Paralog Synthetic Lethal Target in VRK2-methylated Glioblastoma

Julie A. Shields, Samuel R. Meier, Madhavi Bandi, Maria Dam Ferdinez, Justin L. Engel, Erin E. Mulkearns-Hubert, Nicole Hajdari, Kelly Mitchell, Wenhai Zhang, Shan-chuan Zhao, Minjie Zhang, Robert Tjin Tham Sjin, Erik Wilker, Justin D. Lathia, Jannik N. Andersen, Yingnan Chen, Fang Li, Barbara Weber, Alan Huang, View ORCID ProfileNatasha Emmanuel
doi: https://doi.org/10.1101/2021.12.30.474571
Julie A. Shields
1Tango Therapeutics, Cambridge MA
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Samuel R. Meier
1Tango Therapeutics, Cambridge MA
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Madhavi Bandi
1Tango Therapeutics, Cambridge MA
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Maria Dam Ferdinez
1Tango Therapeutics, Cambridge MA
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Justin L. Engel
1Tango Therapeutics, Cambridge MA
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Erin E. Mulkearns-Hubert
2Cleveland Clinic, Cleveland OH
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Nicole Hajdari
2Cleveland Clinic, Cleveland OH
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Kelly Mitchell
2Cleveland Clinic, Cleveland OH
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Wenhai Zhang
1Tango Therapeutics, Cambridge MA
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Shan-chuan Zhao
1Tango Therapeutics, Cambridge MA
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Minjie Zhang
1Tango Therapeutics, Cambridge MA
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Robert Tjin Tham Sjin
1Tango Therapeutics, Cambridge MA
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Erik Wilker
1Tango Therapeutics, Cambridge MA
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Justin D. Lathia
2Cleveland Clinic, Cleveland OH
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Jannik N. Andersen
1Tango Therapeutics, Cambridge MA
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Yingnan Chen
1Tango Therapeutics, Cambridge MA
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Fang Li
1Tango Therapeutics, Cambridge MA
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Barbara Weber
1Tango Therapeutics, Cambridge MA
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Alan Huang
1Tango Therapeutics, Cambridge MA
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Natasha Emmanuel
1Tango Therapeutics, Cambridge MA
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  • ORCID record for Natasha Emmanuel
  • For correspondence: nemmanuel@tangotx.com
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Article Information

doi 
https://doi.org/10.1101/2021.12.30.474571
History 
  • January 1, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Julie A. Shields1,
  2. Samuel R. Meier1,
  3. Madhavi Bandi1,
  4. Maria Dam Ferdinez1,
  5. Justin L. Engel1,
  6. Erin E. Mulkearns-Hubert2,
  7. Nicole Hajdari2,
  8. Kelly Mitchell2,
  9. Wenhai Zhang1,
  10. Shan-chuan Zhao1,
  11. Minjie Zhang1,
  12. Robert Tjin Tham Sjin1,
  13. Erik Wilker1,
  14. Justin D. Lathia2,
  15. Jannik N. Andersen1,
  16. Yingnan Chen1,
  17. Fang Li1,
  18. Barbara Weber1,
  19. Alan Huang1 and
  20. Natasha Emmanuel1,*
  1. 1Tango Therapeutics, Cambridge MA
  2. 2Cleveland Clinic, Cleveland OH
  1. ↵*Corresponding Author:
    Natasha Emmanuel, Tango Therapeutics, 100 Binney Street, Suite 700, Cambridge MA 02114, +1-857-320-4900, nemmanuel{at}tangotx.com
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Posted January 01, 2022.
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VRK1 is a Paralog Synthetic Lethal Target in VRK2-methylated Glioblastoma
Julie A. Shields, Samuel R. Meier, Madhavi Bandi, Maria Dam Ferdinez, Justin L. Engel, Erin E. Mulkearns-Hubert, Nicole Hajdari, Kelly Mitchell, Wenhai Zhang, Shan-chuan Zhao, Minjie Zhang, Robert Tjin Tham Sjin, Erik Wilker, Justin D. Lathia, Jannik N. Andersen, Yingnan Chen, Fang Li, Barbara Weber, Alan Huang, Natasha Emmanuel
bioRxiv 2021.12.30.474571; doi: https://doi.org/10.1101/2021.12.30.474571
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VRK1 is a Paralog Synthetic Lethal Target in VRK2-methylated Glioblastoma
Julie A. Shields, Samuel R. Meier, Madhavi Bandi, Maria Dam Ferdinez, Justin L. Engel, Erin E. Mulkearns-Hubert, Nicole Hajdari, Kelly Mitchell, Wenhai Zhang, Shan-chuan Zhao, Minjie Zhang, Robert Tjin Tham Sjin, Erik Wilker, Justin D. Lathia, Jannik N. Andersen, Yingnan Chen, Fang Li, Barbara Weber, Alan Huang, Natasha Emmanuel
bioRxiv 2021.12.30.474571; doi: https://doi.org/10.1101/2021.12.30.474571

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