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Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant SARS-CoV-2 isolates

Denisa Bojkova, View ORCID ProfileMarek Widera, Sandra Ciesek, View ORCID ProfileMark N. Wass, View ORCID ProfileMartin Michaelis, View ORCID ProfileJindrich Cinatl jr.
doi: https://doi.org/10.1101/2022.01.03.474773
Denisa Bojkova
1Institute for Medical Virology, University Hospital, Goethe University, Frankfurt am Main, Germany
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Marek Widera
1Institute for Medical Virology, University Hospital, Goethe University, Frankfurt am Main, Germany
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  • ORCID record for Marek Widera
Sandra Ciesek
1Institute for Medical Virology, University Hospital, Goethe University, Frankfurt am Main, Germany
2German Center for Infection Research, DZIF, External partner site Frankfurt am Main, Germany
3Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch Translational Medicine und Pharmacology, Frankfurt am Main, Germany
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Mark N. Wass
4School of Biosciences, University of Kent, Canterbury, UK
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  • For correspondence: Cinatl@em.uni-frankfurt.de M.Michaelis@kent.ac.uk M.N.Wass@kent.ac.uk
Martin Michaelis
4School of Biosciences, University of Kent, Canterbury, UK
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  • For correspondence: Cinatl@em.uni-frankfurt.de M.Michaelis@kent.ac.uk M.N.Wass@kent.ac.uk
Jindrich Cinatl jr.
1Institute for Medical Virology, University Hospital, Goethe University, Frankfurt am Main, Germany
5Dr. Petra Joh-Forschungshaus, Frankfurt am Main, Germany
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  • ORCID record for Jindrich Cinatl jr.
  • For correspondence: Cinatl@em.uni-frankfurt.de M.Michaelis@kent.ac.uk M.N.Wass@kent.ac.uk
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Article Information

doi 
https://doi.org/10.1101/2022.01.03.474773
History 
  • January 4, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Denisa Bojkova1,
  2. Marek Widera1,
  3. Sandra Ciesek1,2,3,
  4. Mark N. Wass4,*,
  5. Martin Michaelis4,* and
  6. Jindrich Cinatl jr.1,5,*
  1. 1Institute for Medical Virology, University Hospital, Goethe University, Frankfurt am Main, Germany
  2. 2German Center for Infection Research, DZIF, External partner site Frankfurt am Main, Germany
  3. 3Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch Translational Medicine und Pharmacology, Frankfurt am Main, Germany
  4. 4School of Biosciences, University of Kent, Canterbury, UK
  5. 5Dr. Petra Joh-Forschungshaus, Frankfurt am Main, Germany
  1. ↵*Corresponding authors: Jindrich Cinatl jr., Institute for Medical Virology, University Hospital, Goethe University, Paul Ehrlich-Straße 40, 60596 Frankfurt am Main, Germany; phone +49 69 6301 6409; e-mail Cinatl{at}em.uni-frankfurt.de, Martin Michaelis, School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK; phone +44 1227 82 7804; e-mail M.Michaelis{at}kent.ac.uk, Mark N. Wass, School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK; phone +44 1227 82 7626; e-mail M.N.Wass{at}kent.ac.uk
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Posted January 04, 2022.
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Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant SARS-CoV-2 isolates
Denisa Bojkova, Marek Widera, Sandra Ciesek, Mark N. Wass, Martin Michaelis, Jindrich Cinatl jr.
bioRxiv 2022.01.03.474773; doi: https://doi.org/10.1101/2022.01.03.474773
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Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant SARS-CoV-2 isolates
Denisa Bojkova, Marek Widera, Sandra Ciesek, Mark N. Wass, Martin Michaelis, Jindrich Cinatl jr.
bioRxiv 2022.01.03.474773; doi: https://doi.org/10.1101/2022.01.03.474773

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