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Keeping time and rhythm by replaying a sensory-motor engram

View ORCID ProfileVictor de Lafuente, Mehrdad Jazayeri, Hugo Merchant, Otto Gracía-Garibay, Jaime Cadena-Valencia, Ana M. Malagón
doi: https://doi.org/10.1101/2022.01.03.474812
Victor de Lafuente
1Institute of Neurobiology, National Autonomous University of Mexico. Boulevard Juriquilla 3001, Querétaro, QRO., México, 76230.
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  • ORCID record for Victor de Lafuente
  • For correspondence: lafuente@unam.mx
Mehrdad Jazayeri
2McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA
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Hugo Merchant
1Institute of Neurobiology, National Autonomous University of Mexico. Boulevard Juriquilla 3001, Querétaro, QRO., México, 76230.
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Otto Gracía-Garibay
1Institute of Neurobiology, National Autonomous University of Mexico. Boulevard Juriquilla 3001, Querétaro, QRO., México, 76230.
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Jaime Cadena-Valencia
1Institute of Neurobiology, National Autonomous University of Mexico. Boulevard Juriquilla 3001, Querétaro, QRO., México, 76230.
3Cognitive Neuroscience Laboratory, German Primate Center – Leibniz Institute for Primate Research, Göttingen, 37077, Germany
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Ana M. Malagón
1Institute of Neurobiology, National Autonomous University of Mexico. Boulevard Juriquilla 3001, Querétaro, QRO., México, 76230.
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Abstract

Imagine practicing a piece of music, or a speech, solely within the mind, without any sensory input or motor output. Our ability to implement dynamic internal representations is key for successful behavior, yet how the brain achieves this is not fully understood1–4. Here we trained primates to perceive, and internally maintain, rhythms of different tempos and performed large-scale recordings of neuronal activity across multiple areas spanning the sensory-motor processing hierarchy. Results show that perceiving and maintaining rhythms engage multiple brain areas, including visual, parietal, premotor, prefrontal, and hippocampal regions. Each area displayed oscillatory activity that reflected the temporal and spatial characteristics of an internal metronome which flexibly encoded fast, medium, and slow tempos on a trial-by-trial basis. The presence of widespread metronome-related activity across the brain, in the absence of stimuli and overt actions, is consistent with the idea that time and rhythm are maintained by a mechanism that internally replays the stimuli and actions that define well-timed behavior.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted January 04, 2022.
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Keeping time and rhythm by replaying a sensory-motor engram
Victor de Lafuente, Mehrdad Jazayeri, Hugo Merchant, Otto Gracía-Garibay, Jaime Cadena-Valencia, Ana M. Malagón
bioRxiv 2022.01.03.474812; doi: https://doi.org/10.1101/2022.01.03.474812
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Keeping time and rhythm by replaying a sensory-motor engram
Victor de Lafuente, Mehrdad Jazayeri, Hugo Merchant, Otto Gracía-Garibay, Jaime Cadena-Valencia, Ana M. Malagón
bioRxiv 2022.01.03.474812; doi: https://doi.org/10.1101/2022.01.03.474812

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