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Exploring the rules of chimeric antigen receptor phenotypic output using combinatorial signaling motif libraries and machine learning

K.G. Daniels, View ORCID ProfileS. Wang, M.S. Simic, H.K. Bhargava, S. Capponi, Y. Tonai, W. Yu, S. Bianco, W.A. Lim
doi: https://doi.org/10.1101/2022.01.04.474985
K.G. Daniels
1Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158
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S. Wang
2Department of Functional Genomics and Cellular Engineering, IBM Almaden Research Center, 650 Harry Rd, San Jose, CA 95120
3Center for Cellular Construction, San Francisco, CA, 94158
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  • ORCID record for S. Wang
M.S. Simic
1Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158
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H.K. Bhargava
1Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158
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S. Capponi
2Department of Functional Genomics and Cellular Engineering, IBM Almaden Research Center, 650 Harry Rd, San Jose, CA 95120
3Center for Cellular Construction, San Francisco, CA, 94158
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Y. Tonai
1Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158
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W. Yu
1Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158
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S. Bianco
2Department of Functional Genomics and Cellular Engineering, IBM Almaden Research Center, 650 Harry Rd, San Jose, CA 95120
3Center for Cellular Construction, San Francisco, CA, 94158
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  • For correspondence: sbianco@altoslabs.com wendell.lim@ucsf.edu
W.A. Lim
1Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158
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  • For correspondence: sbianco@altoslabs.com wendell.lim@ucsf.edu
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Article Information

doi 
https://doi.org/10.1101/2022.01.04.474985
History 
  • January 5, 2022.

Article Versions

  • Version 1 (January 4, 2022 - 17:36).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.

Author Information

  1. K.G. Daniels1,
  2. S. Wang2,3,
  3. M.S. Simic1,
  4. H.K. Bhargava1,
  5. S. Capponi2,3,
  6. Y. Tonai1,
  7. W. Yu1,
  8. S. Bianco2,3,&,* and
  9. W.A. Lim1,*
  1. 1Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158
  2. 2Department of Functional Genomics and Cellular Engineering, IBM Almaden Research Center, 650 Harry Rd, San Jose, CA 95120
  3. 3Center for Cellular Construction, San Francisco, CA, 94158
  1. ↵*Correspondence to: sbianco{at}altoslabs.com; wendell.lim{at}ucsf.edu.
  • ↵& Altos Labs, Redwood city, CA

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Posted January 05, 2022.
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Exploring the rules of chimeric antigen receptor phenotypic output using combinatorial signaling motif libraries and machine learning
K.G. Daniels, S. Wang, M.S. Simic, H.K. Bhargava, S. Capponi, Y. Tonai, W. Yu, S. Bianco, W.A. Lim
bioRxiv 2022.01.04.474985; doi: https://doi.org/10.1101/2022.01.04.474985
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Exploring the rules of chimeric antigen receptor phenotypic output using combinatorial signaling motif libraries and machine learning
K.G. Daniels, S. Wang, M.S. Simic, H.K. Bhargava, S. Capponi, Y. Tonai, W. Yu, S. Bianco, W.A. Lim
bioRxiv 2022.01.04.474985; doi: https://doi.org/10.1101/2022.01.04.474985

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