Exploring the rules of chimeric antigen receptor phenotypic output using combinatorial signaling motif libraries and machine learning

K.G. Daniels; S. Wang; M.S. Simic; H.K. Bhargava; S. Capponi; Y. Tonai; W. Yu; S. Bianco; W.A. Lim

doi:10.1101/2022.01.04.474985

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Exploring the rules of chimeric antigen receptor phenotypic output using combinatorial signaling motif libraries and machine learning

K.G. Daniels, View ORCID ProfileS. Wang, M.S. Simic, H.K. Bhargava, S. Capponi, Y. Tonai, W. Yu, S. Bianco, W.A. Lim

doi: https://doi.org/10.1101/2022.01.04.474985

K.G. Daniels

1Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158

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S. Wang

2Department of Functional Genomics and Cellular Engineering, IBM Almaden Research Center, 650 Harry Rd, San Jose, CA 95120

3Center for Cellular Construction, San Francisco, CA, 94158

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ORCID record for S. Wang

M.S. Simic

1Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158

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H.K. Bhargava

1Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158

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S. Capponi

2Department of Functional Genomics and Cellular Engineering, IBM Almaden Research Center, 650 Harry Rd, San Jose, CA 95120

3Center for Cellular Construction, San Francisco, CA, 94158

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Y. Tonai

1Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158

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W. Yu

1Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158

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S. Bianco

2Department of Functional Genomics and Cellular Engineering, IBM Almaden Research Center, 650 Harry Rd, San Jose, CA 95120

3Center for Cellular Construction, San Francisco, CA, 94158

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For correspondence: sbianco@altoslabs.com wendell.lim@ucsf.edu

W.A. Lim

1Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158

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For correspondence: sbianco@altoslabs.com wendell.lim@ucsf.edu

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Exploring the rules of chimeric antigen receptor phenotypic output using combinatorial signaling motif libraries and machine learning

K.G. Daniels, S. Wang, M.S. Simic, H.K. Bhargava, S. Capponi, Y. Tonai, W. Yu, S. Bianco, W.A. Lim

bioRxiv 2022.01.04.474985; doi: https://doi.org/10.1101/2022.01.04.474985

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Exploring the rules of chimeric antigen receptor phenotypic output using combinatorial signaling motif libraries and machine learning

K.G. Daniels, S. Wang, M.S. Simic, H.K. Bhargava, S. Capponi, Y. Tonai, W. Yu, S. Bianco, W.A. Lim

bioRxiv 2022.01.04.474985; doi: https://doi.org/10.1101/2022.01.04.474985

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