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Cancer-driving mutations are enriched in genic regions intolerant to germline variation
View ORCID ProfileDimitrios Vitsios, View ORCID ProfileRyan S. Dhindsa, Jonathan Mitchell, View ORCID ProfileDorota Matelska, Zoe Zou, Joshua Armenia, Quanli Wang, View ORCID ProfileBen Sidders, View ORCID ProfileAndrew R. Harper, View ORCID ProfileSlavé Petrovski
doi: https://doi.org/10.1101/2022.01.07.475416
Dimitrios Vitsios
1Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK
Ryan S. Dhindsa
2Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, USA
3Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
4Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, Houston, TX, USA
Jonathan Mitchell
1Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK
Dorota Matelska
1Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK
Zoe Zou
1Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK
Joshua Armenia
5Bioinformatics and Data Science, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK
Quanli Wang
2Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, USA
Ben Sidders
5Bioinformatics and Data Science, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK
Andrew R. Harper
1Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK
Slavé Petrovski
1Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK
6Department of Medicine, University of Melbourne, Austin Health, Melbourne, Victoria, Australia
Posted January 09, 2022.
Cancer-driving mutations are enriched in genic regions intolerant to germline variation
Dimitrios Vitsios, Ryan S. Dhindsa, Jonathan Mitchell, Dorota Matelska, Zoe Zou, Joshua Armenia, Quanli Wang, Ben Sidders, Andrew R. Harper, Slavé Petrovski
bioRxiv 2022.01.07.475416; doi: https://doi.org/10.1101/2022.01.07.475416
Cancer-driving mutations are enriched in genic regions intolerant to germline variation
Dimitrios Vitsios, Ryan S. Dhindsa, Jonathan Mitchell, Dorota Matelska, Zoe Zou, Joshua Armenia, Quanli Wang, Ben Sidders, Andrew R. Harper, Slavé Petrovski
bioRxiv 2022.01.07.475416; doi: https://doi.org/10.1101/2022.01.07.475416
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