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Retinal axial motion analysis and implications for real-time correction in human retinal imaging

Yao Cai, View ORCID ProfileKate Grieve, View ORCID ProfilePedro Mecê
doi: https://doi.org/10.1101/2022.01.07.475424
Yao Cai
1Institut Langevin, ESPCI Paris, CNRS, PSL University, Paris, 75005, France
2Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, Paris, France
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Kate Grieve
2Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, Paris, France
3CHNO des Quinze-Vingts, INSERM-DGOS CIC 1423, 28 rue de Charenton, F-75012, Paris, France
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Pedro Mecê
1Institut Langevin, ESPCI Paris, CNRS, PSL University, Paris, 75005, France
4DOTA, ONERA, Université Paris Saclay, F-91123 Palaiseau, France
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  • For correspondence: pedro.mece@onera.fr
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Abstract

High-resolution ophthalmic imaging devices including spectral-domain and full-field optical coherence tomography (SDOCT and FFOCT) are adversely affected by the presence of continuous involuntary retinal axial motion. Here, we thoroughly quantify and characterize retinal axial motion with both high temporal resolution (200,000 A-scans/s) and high axial resolution (4.5 µm), recorded over a typical data acquisition duration of 3 s with an SDOCT device over 14 subjects. We demonstrate that although breath-holding can help decrease large-and-slow drifts, it increases small-and-fast fluctuations, which is not ideal when motion compensation is desired. Finally, by simulating the action of an axial motion stabilization control loop, we show that a loop rate of 1.2 kHz is ideal to achieve 100% robust clinical in-vivo retinal imaging.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 10, 2022.
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Retinal axial motion analysis and implications for real-time correction in human retinal imaging
Yao Cai, Kate Grieve, Pedro Mecê
bioRxiv 2022.01.07.475424; doi: https://doi.org/10.1101/2022.01.07.475424
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Retinal axial motion analysis and implications for real-time correction in human retinal imaging
Yao Cai, Kate Grieve, Pedro Mecê
bioRxiv 2022.01.07.475424; doi: https://doi.org/10.1101/2022.01.07.475424

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