Single-cell network biology characterizes cell type gene regulation for drug repurposing and phenotype prediction in Alzheimer’s disease

Chirag Gupta; Jielin Xu; Ting Jin; Saniya Khullar; Xiaoyu Liu; Sayali Alatkar; Feixiong Cheng; Daifeng Wang

doi:10.1101/2022.01.09.475548

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Single-cell network biology characterizes cell type gene regulation for drug repurposing and phenotype prediction in Alzheimer’s disease

Chirag Gupta, Jielin Xu, Ting Jin, Saniya Khullar, Xiaoyu Liu, Sayali Alatkar, Feixiong Cheng, View ORCID ProfileDaifeng Wang

doi: https://doi.org/10.1101/2022.01.09.475548

Chirag Gupta

1Waisman Center, University of Wisconsin-Madison, Madison, WI, 53705, USA

2Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53076, USA

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Jielin Xu

3Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA

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Ting Jin

1Waisman Center, University of Wisconsin-Madison, Madison, WI, 53705, USA

2Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53076, USA

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Saniya Khullar

1Waisman Center, University of Wisconsin-Madison, Madison, WI, 53705, USA

2Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53076, USA

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Xiaoyu Liu

4Department of Statistics, University of Wisconsin-Madison, Madison, WI 53076, USA

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Sayali Alatkar

1Waisman Center, University of Wisconsin-Madison, Madison, WI, 53705, USA

5Department of Computer Sciences, University of Wisconsin-Madison, Madison, WI 53076, USA

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Feixiong Cheng

3Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA

6Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA

7Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA

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Daifeng Wang

1Waisman Center, University of Wisconsin-Madison, Madison, WI, 53705, USA

2Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53076, USA

5Department of Computer Sciences, University of Wisconsin-Madison, Madison, WI 53076, USA

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ORCID record for Daifeng Wang
For correspondence: daifeng.wang@wisc.edu

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Single-cell network biology characterizes cell type gene regulation for drug repurposing and phenotype prediction in Alzheimer’s disease

Chirag Gupta, Jielin Xu, Ting Jin, Saniya Khullar, Xiaoyu Liu, Sayali Alatkar, Feixiong Cheng, Daifeng Wang

bioRxiv 2022.01.09.475548; doi: https://doi.org/10.1101/2022.01.09.475548

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Single-cell network biology characterizes cell type gene regulation for drug repurposing and phenotype prediction in Alzheimer’s disease

Chirag Gupta, Jielin Xu, Ting Jin, Saniya Khullar, Xiaoyu Liu, Sayali Alatkar, Feixiong Cheng, Daifeng Wang

bioRxiv 2022.01.09.475548; doi: https://doi.org/10.1101/2022.01.09.475548

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