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Low and high frequency intracranial neural signals match in the human associative cortex

Corentin Jacques, Jacques Jonas, Sophie Colnat-Coulbois, Louis Maillard, View ORCID ProfileBruno Rossion
doi: https://doi.org/10.1101/2022.01.09.475577
Corentin Jacques
1Université de Lorraine, CNRS, CRAN, F-54000 Nancy, France
2Psychological Sciences Research Institute (IPSY), Université Catholique de Louvain (UCLouvain), 1348, Louvain-la-Neuve, Belgium
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Jacques Jonas
1Université de Lorraine, CNRS, CRAN, F-54000 Nancy, France
3Université de Lorraine, CHRU-Nancy, Service de Neurologie, F-54000 Nancy, France
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Sophie Colnat-Coulbois
4Université de Lorraine, CHRU-Nancy, Service de Neurochirurgie, F-54000 Nancy, France
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Louis Maillard
1Université de Lorraine, CNRS, CRAN, F-54000 Nancy, France
3Université de Lorraine, CHRU-Nancy, Service de Neurologie, F-54000 Nancy, France
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Bruno Rossion
1Université de Lorraine, CNRS, CRAN, F-54000 Nancy, France
3Université de Lorraine, CHRU-Nancy, Service de Neurologie, F-54000 Nancy, France
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  • ORCID record for Bruno Rossion
  • For correspondence: bruno.rossion@univ-lorraine.fr
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ABSTRACT

In vivo intracranial recordings of neural activity offer a unique opportunity to understand human brain function. Intracranial electrophysiological (iEEG) activity related to sensory, cognitive or motor events manifests mostly in two types of signals: event-related local field potentials in lower frequency bands (<30 Hz, LF) and broadband activity in the higher end of the frequency spectrum (>30 Hz, High frequency, HF). While most current studies rely exclusively on HF, thought to be more focal and closely related to spiking activity, the relationship between HF and LF signals is unclear, especially in human associative cortex. Here we provide a large-scale in-depth investigation of the spatial and functional relationship between these 2 signals based on intracranial recordings from 121 individual brains (8000 recording sites). We measure selective responses to complex ecologically salient visual stimuli – human faces - across a wide cortical territory in the ventral occipito-temporal cortex (VOTC), with a frequency-tagging method providing high signal-to-noise ratio (SNR) and the same objective quantification of signal and noise for the two frequency ranges. While LF face-selective activity has higher SNR across the VOTC, leading to a larger number of significant electrode contacts especially in the anterior temporal lobe, LF and HF display highly similar spatial, functional, and timing properties. Specifically, and contrary to a widespread assumption, our results point to nearly identical spatial distribution and local spatial extent of LF and HF activity at equal SNR. These observations go a long way towards clarifying the relationship between the two main iEEG signals and reestablish the informative value of LF iEEG to understand human brain function.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted January 12, 2022.
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Low and high frequency intracranial neural signals match in the human associative cortex
Corentin Jacques, Jacques Jonas, Sophie Colnat-Coulbois, Louis Maillard, Bruno Rossion
bioRxiv 2022.01.09.475577; doi: https://doi.org/10.1101/2022.01.09.475577
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Low and high frequency intracranial neural signals match in the human associative cortex
Corentin Jacques, Jacques Jonas, Sophie Colnat-Coulbois, Louis Maillard, Bruno Rossion
bioRxiv 2022.01.09.475577; doi: https://doi.org/10.1101/2022.01.09.475577

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