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Actin-microtubule dynamic composite forms responsive active matter with memory

View ORCID ProfileOndřej Kučera, Jérémie Gaillard, Christophe Guérin, View ORCID ProfileManuel Théry, View ORCID ProfileLaurent Blanchoin
doi: https://doi.org/10.1101/2022.01.10.475629
Ondřej Kučera
1CytoMorpho Lab, Laboratoire de Physiologie Cellulaire et Végétale, Interdisciplinary Research Institute of Grenoble, CEA/CNRS/Université Grenoble Alpes, Grenoble, France
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  • ORCID record for Ondřej Kučera
  • For correspondence: ondrej.kucera@biophysics.cz manuel.thery@cea.fr laurent.blanchoin@cea.fr
Jérémie Gaillard
1CytoMorpho Lab, Laboratoire de Physiologie Cellulaire et Végétale, Interdisciplinary Research Institute of Grenoble, CEA/CNRS/Université Grenoble Alpes, Grenoble, France
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Christophe Guérin
1CytoMorpho Lab, Laboratoire de Physiologie Cellulaire et Végétale, Interdisciplinary Research Institute of Grenoble, CEA/CNRS/Université Grenoble Alpes, Grenoble, France
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Manuel Théry
1CytoMorpho Lab, Laboratoire de Physiologie Cellulaire et Végétale, Interdisciplinary Research Institute of Grenoble, CEA/CNRS/Université Grenoble Alpes, Grenoble, France
2CytoMorpho Lab, Unité de Thérapie Cellulaire, Hôpital Saint Louis/CNRS/CEA, Paris, France
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  • For correspondence: ondrej.kucera@biophysics.cz manuel.thery@cea.fr laurent.blanchoin@cea.fr
Laurent Blanchoin
1CytoMorpho Lab, Laboratoire de Physiologie Cellulaire et Végétale, Interdisciplinary Research Institute of Grenoble, CEA/CNRS/Université Grenoble Alpes, Grenoble, France
2CytoMorpho Lab, Unité de Thérapie Cellulaire, Hôpital Saint Louis/CNRS/CEA, Paris, France
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  • ORCID record for Laurent Blanchoin
  • For correspondence: ondrej.kucera@biophysics.cz manuel.thery@cea.fr laurent.blanchoin@cea.fr
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Abstract

Active cytoskeletal materials in vitro demonstrate self-organising properties similar to those observed in their counterparts in cells. However, the search to emulate phenomena observed in the living matter has fallen short of producing a cytoskeletal network that would be structurally stable yet possessing adaptive plasticity. Here, we address this challenge by combining cytoskeletal polymers in a composite, where self-assembling microtubules and actin filaments collectively self-organise due to the activity of microtubules-percolating molecular motors. We demonstrate that microtubules spatially organise actin filaments that in turn guide microtubules. The two networks align in an ordered fashion using this feedback loop. In this composite, actin filaments can act as structural memory and, depending on the concentration of the components, microtubules either write this memory or get guided by it. The system is sensitive to external stimuli suggesting possible autoregulatory behaviour in changing mechanochemical environment. We thus establish artificial active actin-microtubule composite as a system demonstrating architectural stability and plasticity.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted January 11, 2022.
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Actin-microtubule dynamic composite forms responsive active matter with memory
Ondřej Kučera, Jérémie Gaillard, Christophe Guérin, Manuel Théry, Laurent Blanchoin
bioRxiv 2022.01.10.475629; doi: https://doi.org/10.1101/2022.01.10.475629
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Actin-microtubule dynamic composite forms responsive active matter with memory
Ondřej Kučera, Jérémie Gaillard, Christophe Guérin, Manuel Théry, Laurent Blanchoin
bioRxiv 2022.01.10.475629; doi: https://doi.org/10.1101/2022.01.10.475629

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