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A pleiotropic chemoreceptor facilitates the functional coupling of pheromone production and perception

View ORCID ProfileCassondra Vernier, Kathleen M. Zelle, View ORCID ProfileNicole Leitner, View ORCID ProfileXitong Liang, View ORCID ProfileSean Halloran, View ORCID ProfileJocelyn G. Millar, View ORCID ProfileYehuda Ben-Shahar
doi: https://doi.org/10.1101/2022.01.10.475668
Cassondra Vernier
1Department of Biology, Washington University in Saint Louis, 1 Brookings Drive, Saint Louis, MO 63130, USA
2Carl R. Woese Institute for Genomic Biology, University of Illinois, 1206 W. Gregory Dr., Urbana, IL 61801, USA
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Kathleen M. Zelle
1Department of Biology, Washington University in Saint Louis, 1 Brookings Drive, Saint Louis, MO 63130, USA
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Nicole Leitner
1Department of Biology, Washington University in Saint Louis, 1 Brookings Drive, Saint Louis, MO 63130, USA
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Xitong Liang
3Department of Neuroscience, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA
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Sean Halloran
4Department of Entomology, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA
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Jocelyn G. Millar
4Department of Entomology, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA
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Yehuda Ben-Shahar
1Department of Biology, Washington University in Saint Louis, 1 Brookings Drive, Saint Louis, MO 63130, USA
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  • For correspondence: benshahary@wustl.edu
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SUMMARY

Optimal mating decisions depend on the robust coupling of signal production and perception because independent changes in either could carry a fitness cost. However, since the perception and production of mating signals are often mediated by different tissues and cell types, the mechanisms that drive and maintain their coupling remain unknown for most animal species. Here, we show that in Drosophila, sensory perception and production of an inhibitory mating pheromone are co-regulated by Gr8a, a member of the Gustatory receptor gene family. Specifically, we found that the pleiotropic action of Gr8a independently regulates the perception of pheromones by the chemosensory systems of males and females, as well as their production in the fat body and oenocytes of males. These findings provide a relatively simple molecular explanation for how pleiotropic receptors maintain robust mating signaling systems at the population and species levels.

Competing Interest Statement

The authors have declared no competing interest.

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Posted January 10, 2022.
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A pleiotropic chemoreceptor facilitates the functional coupling of pheromone production and perception
Cassondra Vernier, Kathleen M. Zelle, Nicole Leitner, Xitong Liang, Sean Halloran, Jocelyn G. Millar, Yehuda Ben-Shahar
bioRxiv 2022.01.10.475668; doi: https://doi.org/10.1101/2022.01.10.475668
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A pleiotropic chemoreceptor facilitates the functional coupling of pheromone production and perception
Cassondra Vernier, Kathleen M. Zelle, Nicole Leitner, Xitong Liang, Sean Halloran, Jocelyn G. Millar, Yehuda Ben-Shahar
bioRxiv 2022.01.10.475668; doi: https://doi.org/10.1101/2022.01.10.475668

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