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Reciprocal epigenetic Sox2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer
Zainab Shonibare, Mehri Monavarian, Kathleen O’ Connell, Diego Altomare, Abigail Shelton, Shubham Mehta, Renata Jaskula-Sztul, Rebecca Phaeton, Mark D. Starr, Regina Whitaker, Andrew Berchuck, Andrew B Nixon, Rebecca Arend, Nam Y Lee, C. Ryan Miller, Nadine Hempel, Karthikeyan Mythreye
doi: https://doi.org/10.1101/2022.01.11.475900
Zainab Shonibare
1Division of Molecular Cellular Pathology, Department of Pathology, O’Neal Comprehensive Cancer Center, University of Alabama School of Medicine, Birmingham, AL, USA
2Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA
Mehri Monavarian
1Division of Molecular Cellular Pathology, Department of Pathology, O’Neal Comprehensive Cancer Center, University of Alabama School of Medicine, Birmingham, AL, USA
Kathleen O’ Connell
2Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA
Diego Altomare
3Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA
Abigail Shelton
4Division of Neuropathology, Department of Pathology, O’Neal Comprehensive Cancer Center, Comprehensive Neuroscience Center, University of Alabama School of Medicine, Birmingham, AL, USA
Shubham Mehta
2Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA
Renata Jaskula-Sztul
5Department of Surgery, University of Alabama School of Medicine, Birmingham, AL, USA
Rebecca Phaeton
6Department of Obstetrics and Gynecology, and Microbiology and Immunology, College of Medicine, Pennsylvania State University, Hershey, PA, USA
Mark D. Starr
7Department of Medicine and Duke Cancer Institute, Duke University Medical Center, Durham NC
Regina Whitaker
8Department of Obstetrics and Gynecology, Duke University Medical Center, Durham NC
Andrew Berchuck
8Department of Obstetrics and Gynecology, Duke University Medical Center, Durham NC
Andrew B Nixon
7Department of Medicine and Duke Cancer Institute, Duke University Medical Center, Durham NC
Rebecca Arend
9Department of Gynecology Oncology, University of Alabama School of Medicine, Birmingham, AL, USA
Nam Y Lee
10Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, AZ, 85721, USA
C. Ryan Miller
4Division of Neuropathology, Department of Pathology, O’Neal Comprehensive Cancer Center, Comprehensive Neuroscience Center, University of Alabama School of Medicine, Birmingham, AL, USA
Nadine Hempel
11Department of Pharmacology, and Obstetrics and Gynecology, College of Medicine, Pennsylvania State University, Hershey, PA, USA
12Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine Pittsburgh PA 15213
Karthikeyan Mythreye
1Division of Molecular Cellular Pathology, Department of Pathology, O’Neal Comprehensive Cancer Center, University of Alabama School of Medicine, Birmingham, AL, USA
2Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA
Posted January 12, 2022.
Reciprocal epigenetic Sox2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer
Zainab Shonibare, Mehri Monavarian, Kathleen O’ Connell, Diego Altomare, Abigail Shelton, Shubham Mehta, Renata Jaskula-Sztul, Rebecca Phaeton, Mark D. Starr, Regina Whitaker, Andrew Berchuck, Andrew B Nixon, Rebecca Arend, Nam Y Lee, C. Ryan Miller, Nadine Hempel, Karthikeyan Mythreye
bioRxiv 2022.01.11.475900; doi: https://doi.org/10.1101/2022.01.11.475900
Reciprocal epigenetic Sox2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer
Zainab Shonibare, Mehri Monavarian, Kathleen O’ Connell, Diego Altomare, Abigail Shelton, Shubham Mehta, Renata Jaskula-Sztul, Rebecca Phaeton, Mark D. Starr, Regina Whitaker, Andrew Berchuck, Andrew B Nixon, Rebecca Arend, Nam Y Lee, C. Ryan Miller, Nadine Hempel, Karthikeyan Mythreye
bioRxiv 2022.01.11.475900; doi: https://doi.org/10.1101/2022.01.11.475900
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