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Video based phenotyping platform for the laboratory mouse

Glen Beane, Brian Q. Geuther, Thomas J. Sproule, Jarek Trapszo, Leinani Hession, Vivek Kohar, View ORCID ProfileVivek Kumar
doi: https://doi.org/10.1101/2022.01.13.476229
Glen Beane
1The Jackson Laboratory, 600 Main Street, Bar Harbor ME 04609
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Brian Q. Geuther
1The Jackson Laboratory, 600 Main Street, Bar Harbor ME 04609
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Thomas J. Sproule
1The Jackson Laboratory, 600 Main Street, Bar Harbor ME 04609
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Jarek Trapszo
1The Jackson Laboratory, 600 Main Street, Bar Harbor ME 04609
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Leinani Hession
1The Jackson Laboratory, 600 Main Street, Bar Harbor ME 04609
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Vivek Kohar
1The Jackson Laboratory, 600 Main Street, Bar Harbor ME 04609
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Vivek Kumar
1The Jackson Laboratory, 600 Main Street, Bar Harbor ME 04609
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  • ORCID record for Vivek Kumar
  • For correspondence: vivek.kumar@jax.org
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Abstract

Automated detection of complex animal behavior remains a challenge in behavioral neurogenetics. Developments in computer-vision have greatly advanced automated behavior detection and allow high-throughput pre-clinical studies. An integrated hardware and software solution is necessary to facilitate the adoption of these advances in the field of behavioral neurogenetics, particularly for non-computational labs. We have published a series of papers using an open field arena to annotate complex behaviors such as grooming, posture, and gait as well as higher level constructs such as frailty. Here, we describe in detail our integrated hardware and software solution for robust, high quality video monitoring of mice. We provide safety data for mice in long-term monitoring by recording environmental conditions in the arenas as well as health markers. The details provided here offer one potential solution for standardized high quality video data for computer vision tasks, and enables replication of our work.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • https://github.com/KumarLabJax/JABS-data-pipeline/tree/main

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted January 18, 2022.
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Video based phenotyping platform for the laboratory mouse
Glen Beane, Brian Q. Geuther, Thomas J. Sproule, Jarek Trapszo, Leinani Hession, Vivek Kohar, Vivek Kumar
bioRxiv 2022.01.13.476229; doi: https://doi.org/10.1101/2022.01.13.476229
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Video based phenotyping platform for the laboratory mouse
Glen Beane, Brian Q. Geuther, Thomas J. Sproule, Jarek Trapszo, Leinani Hession, Vivek Kohar, Vivek Kumar
bioRxiv 2022.01.13.476229; doi: https://doi.org/10.1101/2022.01.13.476229

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