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Intracortical microstimulation pulse waveform and frequency recruits distinct spatiotemporal patterns of cortical neuron and neuropil activation

Kevin C. Stieger, James R. Eles, Kip A. Ludwig, View ORCID ProfileTakashi D.Y. Kozai
doi: https://doi.org/10.1101/2022.01.14.476351
Kevin C. Stieger
1Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA
2Center for the Neural Basis of Cognition, University of Pittsburgh, Carnegie Mellon University, Pittsburgh, PA
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James R. Eles
1Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA
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Kip A. Ludwig
3Department of Biomedical Engineering, University of Wisconsin Madison, Madison, Wisconsin
4Department of Neurological Surgery, University of Wisconsin Madison, Madison, Wisconsin
5Wisconsin Institute for Translational Neuroengineering (WITNe), Madison, Wisconsin, USA
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Takashi D.Y. Kozai
1Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA
2Center for the Neural Basis of Cognition, University of Pittsburgh, Carnegie Mellon University, Pittsburgh, PA
6Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA
7McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA
8NeuroTech Center, University of Pittsburgh Brain Institute, Pittsburgh, PA
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  • ORCID record for Takashi D.Y. Kozai
  • For correspondence: tdk18@pitt.edu
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Article Information

doi 
https://doi.org/10.1101/2022.01.14.476351
History 
  • January 17, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Kevin C. Stieger1,2,
  2. James R. Eles1,
  3. Kip A. Ludwig3,4,5 and
  4. Takashi D.Y. Kozai1,2,6,7,8,*
  1. 1Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA
  2. 2Center for the Neural Basis of Cognition, University of Pittsburgh, Carnegie Mellon University, Pittsburgh, PA
  3. 3Department of Biomedical Engineering, University of Wisconsin Madison, Madison, Wisconsin
  4. 4Department of Neurological Surgery, University of Wisconsin Madison, Madison, Wisconsin
  5. 5Wisconsin Institute for Translational Neuroengineering (WITNe), Madison, Wisconsin, USA
  6. 6Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA
  7. 7McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA
  8. 8NeuroTech Center, University of Pittsburgh Brain Institute, Pittsburgh, PA
  1. ↵*Correspondence: Takashi D.Y. Kozai. Department of Bioengineering, University of Pittsburgh, 208 Center for Biotechnology and Bioengineering, 300 Technology Dr., Pittsburgh, PA 15219. Phone: 412-383-9044, Email: tdk18{at}pitt.edu
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Posted January 17, 2022.
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Intracortical microstimulation pulse waveform and frequency recruits distinct spatiotemporal patterns of cortical neuron and neuropil activation
Kevin C. Stieger, James R. Eles, Kip A. Ludwig, Takashi D.Y. Kozai
bioRxiv 2022.01.14.476351; doi: https://doi.org/10.1101/2022.01.14.476351
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Intracortical microstimulation pulse waveform and frequency recruits distinct spatiotemporal patterns of cortical neuron and neuropil activation
Kevin C. Stieger, James R. Eles, Kip A. Ludwig, Takashi D.Y. Kozai
bioRxiv 2022.01.14.476351; doi: https://doi.org/10.1101/2022.01.14.476351

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