Article Information
History
- January 18, 2022.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Author Information
- Amanda L Tatler1,+,
- Christopher J Philp1,+,
- Michael R Hill2,+,
- Sam Cox3,
- Andrew Bullock2,
- Anthony Habgood1,
- Alison John1,
- Robert Middlewick1,
- Katherine E Stephenson1,
- Amanda T Goodwin1,
- Charlotte K Billington1,
- Reuben D O’Dea2,
- Bindi S Brook2,# and
- Simon R Johnson1,#,*
- 1Centre for Respiratory Research, NIHR Biomedical Research Centre and Biodiscovery Institute, School of Medicine, University of Nottingham
- 2School of Mathematical Sciences, University of Nottingham
- 3Digital Research Service, University of Nottingham
- ↵*Address correspondence to: Simon R Johnson; simon.johnson{at}nottingham.ac.uk; Tel: +44 (0)115 823 1063; fax: +44 (0) 115 823 1059.
↵+ First authors contributed equally to this manuscript
Contributions:
Experimental work: CJP, CKB, ALT, AH, AEJ, RM, KES, ATG
Conception and design of the study: CJP, MRH, CKB, ALT, RDO, BSB, SRJ
Analysis and interpretation: CJP, MRH, CKB, ALT, RDO, BSB, SRJ
Image analysis computational code: MRH, AB, SC, RDO, BSB
Drafting the manuscript for important intellectual content: CJP, MRH, CKB, AB, ALT, RDO, BSB, SRJ ALT, CJP and MRH performed the animal work, airway analysis and mathematical analysis respectively, giving equal contributions to the work.