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A novel mechanism for left-right asymmetry establishment involving tissue remodeling and MyoID

View ORCID ProfileBénédicte M. Lefèvre, Marine Delvigne, Josué Vidal, View ORCID ProfileVirginie Courtier-Orgogozo, View ORCID ProfileMichael Lang
doi: https://doi.org/10.1101/2022.01.16.476383
Bénédicte M. Lefèvre
1Université de Paris, CNRS, Institut Jacques Monod, F-75013 Paris, France
2Team “Stem Cells and Tissue Homeostasis”, Institut Curie, CNRS, UMR3215, INSERM U934, PSL Research University, 26 rue d’Ulm, 75248 Paris Cedex 05
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Marine Delvigne
1Université de Paris, CNRS, Institut Jacques Monod, F-75013 Paris, France
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Josué Vidal
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Virginie Courtier-Orgogozo
1Université de Paris, CNRS, Institut Jacques Monod, F-75013 Paris, France
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  • For correspondence: michael.lang@ijm.fr virginie.courtier@normalesup.org
Michael Lang
1Université de Paris, CNRS, Institut Jacques Monod, F-75013 Paris, France
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  • For correspondence: michael.lang@ijm.fr virginie.courtier@normalesup.org
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Abstract

How novel left-right asymmetries evolve in animals is unknown. Drosophila pachea males display a unique left-right asymmetry in the genital organs and mate in a right-sided position onto the female. In flies, male genitalia undergo a clockwise 360° rotation during development. To test if this tissue remodeling process is linked to asymmetry development in the male genitalia of Drosophila pachea, we developed CRIPSR and transgenesis in this singular species. As in D. melanogaster, mutants of the MyoID gene homolog undergo reverse rotation of the developing genitalia. In addition, they have mirror-image asymmetric genitalia. Although their genital asymmetry is reversed mutants still adopt a right-sided copulation posture. Our results reveal a novel mechanism for establishing left-right asymmetry in animals, involving complex tissue remodeling and MyoID.

One Sentence Summary D. pachea genital left-right size asymmetry is established through MyoID-mediated tissue remodelling and does not determine the direction of mating posture.

Competing Interest Statement

The authors have declared no competing interest.

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Posted January 17, 2022.
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A novel mechanism for left-right asymmetry establishment involving tissue remodeling and MyoID
Bénédicte M. Lefèvre, Marine Delvigne, Josué Vidal, Virginie Courtier-Orgogozo, Michael Lang
bioRxiv 2022.01.16.476383; doi: https://doi.org/10.1101/2022.01.16.476383
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A novel mechanism for left-right asymmetry establishment involving tissue remodeling and MyoID
Bénédicte M. Lefèvre, Marine Delvigne, Josué Vidal, Virginie Courtier-Orgogozo, Michael Lang
bioRxiv 2022.01.16.476383; doi: https://doi.org/10.1101/2022.01.16.476383

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