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Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease relevant pathologies
Nadeem Murtaza, Annie A. Cheng, Chad O. Brown, Durga Praveen Meka, Shuai Hong, Jarryll A. Uy, Joelle El-Hajjar, Neta Pipko, Brianna K. Unda, Birgit Schwanke, Sansi Xing, Bhooma Thiruvahindrapuram, Worrawat Engchuan, Brett Trost, Eric Deneault, Froylan Calderon de Anda, Bradley W. Doble, James Ellis, Evdokia Anagnostou, View ORCID ProfileGary D. Bader, Stephen W. Scherer, Yu Lu, Karun K. Singh
doi: https://doi.org/10.1101/2022.01.17.476220
Nadeem Murtaza
1Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
2Krembil Research Institute, University Health Network, Toronto, ON, Canada
Annie A. Cheng
2Krembil Research Institute, University Health Network, Toronto, ON, Canada
Chad O. Brown
1Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
2Krembil Research Institute, University Health Network, Toronto, ON, Canada
Durga Praveen Meka
3Center for Molecular Neurobiology Hamburg (ZMNH), Research Group Neuronal Development, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany
Shuai Hong
3Center for Molecular Neurobiology Hamburg (ZMNH), Research Group Neuronal Development, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany
Jarryll A. Uy
2Krembil Research Institute, University Health Network, Toronto, ON, Canada
4Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
Joelle El-Hajjar
1Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
Neta Pipko
1Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
Brianna K. Unda
2Krembil Research Institute, University Health Network, Toronto, ON, Canada
Birgit Schwanke
3Center for Molecular Neurobiology Hamburg (ZMNH), Research Group Neuronal Development, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany
Sansi Xing
1Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
Bhooma Thiruvahindrapuram
5The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada
Worrawat Engchuan
5The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada
Brett Trost
5The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada
Eric Deneault
6Centre for Biologics Evaluation, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada
Froylan Calderon de Anda
3Center for Molecular Neurobiology Hamburg (ZMNH), Research Group Neuronal Development, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany
Bradley W. Doble
7Department of Paediatrics, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada
James Ellis
5The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada
8Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
Evdokia Anagnostou
9Department of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.
10Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.
Gary D. Bader
8Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
Stephen W. Scherer
5The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada
8Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
Yu Lu
1Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
Karun K. Singh
2Krembil Research Institute, University Health Network, Toronto, ON, Canada
4Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
Posted January 19, 2022.
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease relevant pathologies
Nadeem Murtaza, Annie A. Cheng, Chad O. Brown, Durga Praveen Meka, Shuai Hong, Jarryll A. Uy, Joelle El-Hajjar, Neta Pipko, Brianna K. Unda, Birgit Schwanke, Sansi Xing, Bhooma Thiruvahindrapuram, Worrawat Engchuan, Brett Trost, Eric Deneault, Froylan Calderon de Anda, Bradley W. Doble, James Ellis, Evdokia Anagnostou, Gary D. Bader, Stephen W. Scherer, Yu Lu, Karun K. Singh
bioRxiv 2022.01.17.476220; doi: https://doi.org/10.1101/2022.01.17.476220
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease relevant pathologies
Nadeem Murtaza, Annie A. Cheng, Chad O. Brown, Durga Praveen Meka, Shuai Hong, Jarryll A. Uy, Joelle El-Hajjar, Neta Pipko, Brianna K. Unda, Birgit Schwanke, Sansi Xing, Bhooma Thiruvahindrapuram, Worrawat Engchuan, Brett Trost, Eric Deneault, Froylan Calderon de Anda, Bradley W. Doble, James Ellis, Evdokia Anagnostou, Gary D. Bader, Stephen W. Scherer, Yu Lu, Karun K. Singh
bioRxiv 2022.01.17.476220; doi: https://doi.org/10.1101/2022.01.17.476220
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