New Results
Dual Targeting of FLT3 and LSD1 Disrupts the MYC Super-Enhancer Complex in Acute Myeloid Leukemia
View ORCID ProfileWilliam Yashar, View ORCID ProfileBrittany M. Smith, View ORCID ProfileDaniel J. Coleman, View ORCID ProfileJake VanCampen, View ORCID ProfileGarth Kong, Jommel Macaraeg, Joseph Estabrook, View ORCID ProfileEmek Demir, View ORCID ProfileNicola Long, Dan Bottomly, View ORCID ProfileShannon K. McWeeney, View ORCID ProfileJeffrey W. Tyner, View ORCID ProfileBrian J. Druker, View ORCID ProfileJulia E. Maxson, View ORCID ProfileTheodore P. Braun
doi: https://doi.org/10.1101/2022.01.17.476469
William Yashar
1Knight Cancer Institute, Oregon Health & Science University, Portland, OR, 97239, USA
2Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University, Portland, OR, 97239, USA
Brittany M. Smith
1Knight Cancer Institute, Oregon Health & Science University, Portland, OR, 97239, USA
2Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University, Portland, OR, 97239, USA
Daniel J. Coleman
1Knight Cancer Institute, Oregon Health & Science University, Portland, OR, 97239, USA
Jake VanCampen
1Knight Cancer Institute, Oregon Health & Science University, Portland, OR, 97239, USA
2Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University, Portland, OR, 97239, USA
Garth Kong
1Knight Cancer Institute, Oregon Health & Science University, Portland, OR, 97239, USA
2Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University, Portland, OR, 97239, USA
Jommel Macaraeg
1Knight Cancer Institute, Oregon Health & Science University, Portland, OR, 97239, USA
2Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University, Portland, OR, 97239, USA
Joseph Estabrook
3Cancer Early Detection Advanced Research Center, Oregon Health & Science University, Portland, OR, 97239, USA
Emek Demir
2Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University, Portland, OR, 97239, USA
4Department of Molecular and Medical Genetics, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
5Pacific Northwest National Laboratories, 902 Battelle Blvd, Richland, WA 99354, USA
Nicola Long
1Knight Cancer Institute, Oregon Health & Science University, Portland, OR, 97239, USA
6Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR, 97239, USA
Dan Bottomly
1Knight Cancer Institute, Oregon Health & Science University, Portland, OR, 97239, USA
7Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR, 97239, USA
Shannon K. McWeeney
1Knight Cancer Institute, Oregon Health & Science University, Portland, OR, 97239, USA
7Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR, 97239, USA
Jeffrey W. Tyner
2Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University, Portland, OR, 97239, USA
8Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR, 97239, USA
Brian J. Druker
1Knight Cancer Institute, Oregon Health & Science University, Portland, OR, 97239, USA
2Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University, Portland, OR, 97239, USA
6Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR, 97239, USA
Julia E. Maxson
1Knight Cancer Institute, Oregon Health & Science University, Portland, OR, 97239, USA
2Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University, Portland, OR, 97239, USA
Theodore P. Braun
1Knight Cancer Institute, Oregon Health & Science University, Portland, OR, 97239, USA
2Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University, Portland, OR, 97239, USA
6Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR, 97239, USA
Posted January 18, 2022.
Dual Targeting of FLT3 and LSD1 Disrupts the MYC Super-Enhancer Complex in Acute Myeloid Leukemia
William Yashar, Brittany M. Smith, Daniel J. Coleman, Jake VanCampen, Garth Kong, Jommel Macaraeg, Joseph Estabrook, Emek Demir, Nicola Long, Dan Bottomly, Shannon K. McWeeney, Jeffrey W. Tyner, Brian J. Druker, Julia E. Maxson, Theodore P. Braun
bioRxiv 2022.01.17.476469; doi: https://doi.org/10.1101/2022.01.17.476469
Dual Targeting of FLT3 and LSD1 Disrupts the MYC Super-Enhancer Complex in Acute Myeloid Leukemia
William Yashar, Brittany M. Smith, Daniel J. Coleman, Jake VanCampen, Garth Kong, Jommel Macaraeg, Joseph Estabrook, Emek Demir, Nicola Long, Dan Bottomly, Shannon K. McWeeney, Jeffrey W. Tyner, Brian J. Druker, Julia E. Maxson, Theodore P. Braun
bioRxiv 2022.01.17.476469; doi: https://doi.org/10.1101/2022.01.17.476469
Subject Area
Subject Areas
- Biochemistry (11715)
- Bioengineering (8723)
- Bioinformatics (29129)
- Biophysics (14936)
- Cancer Biology (12049)
- Cell Biology (17359)
- Clinical Trials (138)
- Developmental Biology (9406)
- Ecology (14144)
- Epidemiology (2067)
- Evolutionary Biology (18268)
- Genetics (12221)
- Genomics (16767)
- Immunology (11843)
- Microbiology (28014)
- Molecular Biology (11560)
- Neuroscience (60814)
- Paleontology (450)
- Pathology (1864)
- Pharmacology and Toxicology (3231)
- Physiology (4940)
- Plant Biology (10384)
- Synthetic Biology (2878)
- Systems Biology (7333)
- Zoology (1642)