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Activation of the Integrated Stress Response overcomes multidrug resistance in FBXW7-deficient cells

Laura Sanchez-Burgos, Belén Navarro-González, Santiago García-Martín, Héctor Tejero, Marta Elena Antón, Fátima Al-Shahrour, Oscar Fernandez-Capetillo
doi: https://doi.org/10.1101/2022.01.17.476566
Laura Sanchez-Burgos
1Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain
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Belén Navarro-González
1Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain
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Santiago García-Martín
2Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain
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Héctor Tejero
2Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain
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Marta Elena Antón
1Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain
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Fátima Al-Shahrour
2Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain
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Oscar Fernandez-Capetillo
1Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain
3Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, S-171 21 Stockholm, Sweden
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  • For correspondence: ofernandez@cnio.es
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Article Information

doi 
https://doi.org/10.1101/2022.01.17.476566
History 
  • January 18, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Laura Sanchez-Burgos1,
  2. Belén Navarro-González1,
  3. Santiago García-Martín2,
  4. Héctor Tejero2,
  5. Marta Elena Antón1,
  6. Fátima Al-Shahrour2 and
  7. Oscar Fernandez-Capetillo1,3,*
  1. 1Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain
  2. 2Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain
  3. 3Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, S-171 21 Stockholm, Sweden
  1. ↵*Lead Contact:
    Oscar Fernandez-Capetillo, Spanish National Cancer Research Centre (CNIO), Melchor Fernandez Almagro, 3, Madrid 28029, Spain, Tel.: +34.91.732.8000 Ext: 3480, Fax: +34.91.732.8028, Email: ofernandez{at}cnio.es, Twitter: @KP_Twitt_llo
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Posted January 18, 2022.
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Activation of the Integrated Stress Response overcomes multidrug resistance in FBXW7-deficient cells
Laura Sanchez-Burgos, Belén Navarro-González, Santiago García-Martín, Héctor Tejero, Marta Elena Antón, Fátima Al-Shahrour, Oscar Fernandez-Capetillo
bioRxiv 2022.01.17.476566; doi: https://doi.org/10.1101/2022.01.17.476566
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Activation of the Integrated Stress Response overcomes multidrug resistance in FBXW7-deficient cells
Laura Sanchez-Burgos, Belén Navarro-González, Santiago García-Martín, Héctor Tejero, Marta Elena Antón, Fátima Al-Shahrour, Oscar Fernandez-Capetillo
bioRxiv 2022.01.17.476566; doi: https://doi.org/10.1101/2022.01.17.476566

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