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High activity of an affinity-matured ACE2 decoy against Omicron SARS-CoV-2 and pre-emergent coronaviruses

View ORCID ProfileJoshua J. Sims, Sharon Lian, Rosemary L. Meggersee, Aradhana Kasimsetty, View ORCID ProfileJames M. Wilson
doi: https://doi.org/10.1101/2022.01.17.476672
Joshua J. Sims
1Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
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  • ORCID record for Joshua J. Sims
Sharon Lian
1Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
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Rosemary L. Meggersee
1Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
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Aradhana Kasimsetty
1Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
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James M. Wilson
1Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
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  • ORCID record for James M. Wilson
  • For correspondence: wilsonjm@upenn.edu
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Article Information

doi 
https://doi.org/10.1101/2022.01.17.476672
History 
  • May 19, 2022.

Article Versions

  • Version 1 (January 19, 2022 - 23:42).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Joshua J. Sims1,
  2. Sharon Lian1,
  3. Rosemary L. Meggersee1,
  4. Aradhana Kasimsetty1 and
  5. James M. Wilson1,*
  1. 1Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
  1. ↵*Corresponding author: James M. Wilson, MD, PhD, Gene Therapy Program, Perelman School of Medicine, University of Pennsylvania, 125 South 31st Street, Suite 1200, Philadelphia, PA 19104, USA, Phone: 215-573-9020; Fax: 215-494-5444, E-mail: wilsonjm{at}upenn.edu
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Posted May 19, 2022.
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High activity of an affinity-matured ACE2 decoy against Omicron SARS-CoV-2 and pre-emergent coronaviruses
Joshua J. Sims, Sharon Lian, Rosemary L. Meggersee, Aradhana Kasimsetty, James M. Wilson
bioRxiv 2022.01.17.476672; doi: https://doi.org/10.1101/2022.01.17.476672
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High activity of an affinity-matured ACE2 decoy against Omicron SARS-CoV-2 and pre-emergent coronaviruses
Joshua J. Sims, Sharon Lian, Rosemary L. Meggersee, Aradhana Kasimsetty, James M. Wilson
bioRxiv 2022.01.17.476672; doi: https://doi.org/10.1101/2022.01.17.476672

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