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BrainStat: A toolbox for brain-wide statistics and neuroscientific contextualization

View ORCID ProfileReinder Vos de Wael, Şeyma Bayrak, View ORCID ProfileOualid Benkarim, Peer Herholz, Sara Larivière, View ORCID ProfileRaul Rodriguez-Cruces, Casey Paquola, Seok-Jun Hong, Bratislav Misic, Alan C. Evans, Sofie L. Valk, View ORCID ProfileBoris C. Bernhardt
doi: https://doi.org/10.1101/2022.01.18.476795
Reinder Vos de Wael
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
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  • ORCID record for Reinder Vos de Wael
Şeyma Bayrak
2Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
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Oualid Benkarim
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
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Peer Herholz
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
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Sara Larivière
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
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Raul Rodriguez-Cruces
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
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  • ORCID record for Raul Rodriguez-Cruces
Casey Paquola
3Institute of Neuroscience and Medicine (INM-1), Forschungszentrum Jülich, Germany
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Seok-Jun Hong
4Child Mind Institute, New York, USA
5Center for Neuroscience Imaging Research, Institute for Basic Science, and Department of Biomedical Engineering, Sungkyunkwan University, Suwon, South Korea
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Bratislav Misic
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
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Alan C. Evans
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
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Sofie L. Valk
2Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
3Institute of Neuroscience and Medicine (INM-1), Forschungszentrum Jülich, Germany
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Boris C. Bernhardt
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
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  • ORCID record for Boris C. Bernhardt
  • For correspondence: boris.bernhardt@mcgill.ca reinder.vosdewael@mail.mcgill.ca
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ABSTRACT

Analysis and interpretation of neuroimaging datasets has become a multidisciplinary endeavor, relying not only on statistical methods, but increasingly on associations with respect to other brain-derived features such as gene expression, histological data, and functional as well as cognitive architectures. Here we introduce BrainStat - a toolbox for (i) univariate and multivariate general linear models in volumetric and surface-based brain imaging datasets, and (ii) multidomain feature association of results with respect to spatial maps of post-mortem gene expression and histology, as well as task-based fMRI meta-analysis, canonical resting-state fMRI networks, and resting-state derived gradients across several common surface templates. The combination of statistics and feature associations into a turnkey toolbox offers to streamline analytical processes and accelerate cross-modal. The toolbox is implemented in both Python and MATLAB, two widely used programming languages in the neuroimaging and neuroinformatics communities. BrainStat is openly available and complemented by an expandable documentation.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted January 21, 2022.
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BrainStat: A toolbox for brain-wide statistics and neuroscientific contextualization
Reinder Vos de Wael, Şeyma Bayrak, Oualid Benkarim, Peer Herholz, Sara Larivière, Raul Rodriguez-Cruces, Casey Paquola, Seok-Jun Hong, Bratislav Misic, Alan C. Evans, Sofie L. Valk, Boris C. Bernhardt
bioRxiv 2022.01.18.476795; doi: https://doi.org/10.1101/2022.01.18.476795
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BrainStat: A toolbox for brain-wide statistics and neuroscientific contextualization
Reinder Vos de Wael, Şeyma Bayrak, Oualid Benkarim, Peer Herholz, Sara Larivière, Raul Rodriguez-Cruces, Casey Paquola, Seok-Jun Hong, Bratislav Misic, Alan C. Evans, Sofie L. Valk, Boris C. Bernhardt
bioRxiv 2022.01.18.476795; doi: https://doi.org/10.1101/2022.01.18.476795

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