Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Ultra-flexible and Stretchable Intrafascicular Peripheral Nerve Recording Device with Axon-dimension, Cuff-less Microneedle Electrode Array

Dongxiao Yan, Ahmad A. Jiman, Elizabeth C. Bottorff, Paras R. Patel, Dilara Meli, Elissa J. Welle, David C. Ratze, Leif A. Havton, Cynthia A. Chestek, Stephen W.P. Kemp, View ORCID ProfileTim M. Bruns, Euisik Yoon, View ORCID ProfileJohn Seymour
doi: https://doi.org/10.1101/2022.01.19.476928
Dongxiao Yan
1Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ahmad A. Jiman
2Department of Electrical and Computer Engineering, King Abdulaziz University, Jeddah, Saudi Arabia
3Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elizabeth C. Bottorff
3Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paras R. Patel
3Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dilara Meli
4Department of Materials Science and Engineering, Northwestern University, Evanston, IL
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elissa J. Welle
3Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David C. Ratze
1Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Leif A. Havton
5Departments of Neurology and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY
6James J Peters Veterans Affairs Medical Center, Bronx, NY
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cynthia A. Chestek
3Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stephen W.P. Kemp
3Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI
7Section of Plastic Surgery, University of Michigan, Ann Arbor, MI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tim M. Bruns
3Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Tim M. Bruns
Euisik Yoon
1Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI
3Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI
8Center for Nanomedicine, Institute for Basic Science (IBS) and Graduate Program of Nano Biomedical Engineering (Nano BME), Advanced Science Institute, Yonsei University, Seoul, South Korea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John Seymour
1Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI
9Department of Neurosurgery, UTHealth, Houston, TX
10Department of Electrical and Computer Engineering, Rice University, Houston, TX
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for John Seymour
  • For correspondence: john.p.seymour@uth.tmc.edu
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

Peripheral nerve mapping tools with higher spatial resolution are needed to advance systems neuroscience, and potentially provide a closed-loop biomarker in neuromodulation applications. Two critical challenges of microscale neural interfaces are (i) how to apply them to small peripheral nerves, and (ii) how to minimize chronic reactivity. We developed a flexible microneedle nerve array (MINA), which is the first high-density penetrating electrode array made with axon-sized silicon microneedles embedded in low-modulus thin silicone. We present the design, fabrication, acute recording, and chronic reactivity to an implanted MINA. Distinctive units were identified in the rat peroneal nerve. We also demonstrate a long-term, cuff-free, and suture-free fixation manner using rose bengal as a light-activated adhesive for two timepoints. The tissue response at 1-week included a sham (N=5) and MINA-implanted (N=5) group, and the response at 6-week also included a sham (N=3) and MINA-implanted (N=4) group. These conditions were quantified in the left vagus nerve of rats using histomorphometry. Micro-CT was added to visualize and quantify tissue encapsulation around the implant. MINA demonstrated a reduction in encapsulation thickness over previously quantified interfascicular methods. Future challenges include techniques for precise insertion of the microneedle electrodes and demonstrating long-term recording.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted January 21, 2022.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Ultra-flexible and Stretchable Intrafascicular Peripheral Nerve Recording Device with Axon-dimension, Cuff-less Microneedle Electrode Array
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Ultra-flexible and Stretchable Intrafascicular Peripheral Nerve Recording Device with Axon-dimension, Cuff-less Microneedle Electrode Array
Dongxiao Yan, Ahmad A. Jiman, Elizabeth C. Bottorff, Paras R. Patel, Dilara Meli, Elissa J. Welle, David C. Ratze, Leif A. Havton, Cynthia A. Chestek, Stephen W.P. Kemp, Tim M. Bruns, Euisik Yoon, John Seymour
bioRxiv 2022.01.19.476928; doi: https://doi.org/10.1101/2022.01.19.476928
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Ultra-flexible and Stretchable Intrafascicular Peripheral Nerve Recording Device with Axon-dimension, Cuff-less Microneedle Electrode Array
Dongxiao Yan, Ahmad A. Jiman, Elizabeth C. Bottorff, Paras R. Patel, Dilara Meli, Elissa J. Welle, David C. Ratze, Leif A. Havton, Cynthia A. Chestek, Stephen W.P. Kemp, Tim M. Bruns, Euisik Yoon, John Seymour
bioRxiv 2022.01.19.476928; doi: https://doi.org/10.1101/2022.01.19.476928

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4237)
  • Biochemistry (9155)
  • Bioengineering (6797)
  • Bioinformatics (24052)
  • Biophysics (12149)
  • Cancer Biology (9562)
  • Cell Biology (13814)
  • Clinical Trials (138)
  • Developmental Biology (7653)
  • Ecology (11729)
  • Epidemiology (2066)
  • Evolutionary Biology (15534)
  • Genetics (10663)
  • Genomics (14346)
  • Immunology (9503)
  • Microbiology (22876)
  • Molecular Biology (9113)
  • Neuroscience (49080)
  • Paleontology (357)
  • Pathology (1487)
  • Pharmacology and Toxicology (2576)
  • Physiology (3851)
  • Plant Biology (8347)
  • Scientific Communication and Education (1473)
  • Synthetic Biology (2299)
  • Systems Biology (6202)
  • Zoology (1302)