Overestimated Polygenic Prediction due to Overlapping Subjects in Genetic Datasets

David Keetae Park; Mingshen Chen; Seungsoo Kim; Yoonjung Yoonie Joo; Rebekah K. Loving; Hyoung Seop Kim; Jiook Cha; Shinjae Yoo; Jong Hun Kim

doi:10.1101/2022.01.19.476997

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Overestimated Polygenic Prediction due to Overlapping Subjects in Genetic Datasets

David Keetae Park, Mingshen Chen, Seungsoo Kim, Yoonjung Yoonie Joo, Rebekah K. Loving, Hyoung Seop Kim, Jiook Cha, Shinjae Yoo, Jong Hun Kim

doi: https://doi.org/10.1101/2022.01.19.476997

David Keetae Park

1Department of Biomedical Engineering, Columbia University, New York, USA

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Mingshen Chen

2Department of Applied Mathematics & Statistics, Stony Brook University, New York, USA

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Seungsoo Kim

3Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA

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Yoonjung Yoonie Joo

4Institute of Data Science, Korea University, Seoul, South Korea

5Department of Psychology, Brain and Cognitive Sciences, AI Institute, Seoul National University, Seoul, South Korea

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Rebekah K. Loving

6Department of Biology, California Institute of Technology, Pasadena, USA

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Hyoung Seop Kim

7Department of Physical Medicine and Rehabilitation, Dementia Center, National Health Insurance Service Ilsan Hospital, Goyang, South Korea

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Jiook Cha

5Department of Psychology, Brain and Cognitive Sciences, AI Institute, Seoul National University, Seoul, South Korea

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Shinjae Yoo

8Computational Science Initiative, Brookhaven National Laboratory, New York, USA

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For correspondence: jh7521@naver.com sjyoo@bnl.gov

Jong Hun Kim

9Department of Neurology, Dementia Center, National Health Insurance Service Ilsan Hospital, Goyang, South Korea

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For correspondence: jh7521@naver.com sjyoo@bnl.gov

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Overestimated Polygenic Prediction due to Overlapping Subjects in Genetic Datasets

David Keetae Park, Mingshen Chen, Seungsoo Kim, Yoonjung Yoonie Joo, Rebekah K. Loving, Hyoung Seop Kim, Jiook Cha, Shinjae Yoo, Jong Hun Kim

bioRxiv 2022.01.19.476997; doi: https://doi.org/10.1101/2022.01.19.476997

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Overestimated Polygenic Prediction due to Overlapping Subjects in Genetic Datasets

David Keetae Park, Mingshen Chen, Seungsoo Kim, Yoonjung Yoonie Joo, Rebekah K. Loving, Hyoung Seop Kim, Jiook Cha, Shinjae Yoo, Jong Hun Kim

bioRxiv 2022.01.19.476997; doi: https://doi.org/10.1101/2022.01.19.476997

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