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Cell cycle dynamics controls fluidity of the developing mouse neuroepithelium

View ORCID ProfileLaura Bocanegra-Moreno, Amrita Singh, View ORCID ProfileEdouard Hannezo, View ORCID ProfileMarcin Zagorski, View ORCID ProfileAnna Kicheva
doi: https://doi.org/10.1101/2022.01.20.477048
Laura Bocanegra-Moreno
1Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria
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Amrita Singh
1Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria
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Edouard Hannezo
1Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria
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Marcin Zagorski
2Institute of Theoretical Physics, Jagiellonian University, Lojasiewicza 11, 30-348 Krakow, Poland
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  • For correspondence: marcin.zagorski@uj.edu.pl anna.kicheva@ist.ac.at
Anna Kicheva
1Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria
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  • For correspondence: marcin.zagorski@uj.edu.pl anna.kicheva@ist.ac.at
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Abstract

As organs are remodelled by morphogenetic changes and pattern formation during development, their material properties may change. To address whether and how this occurs in the mouse neural tube, we combined highly resolved mosaic analysis, biophysical modelling and perturbation experiments. We found that at early developmental stages the neuroepithelium surprisingly maintains both high junctional tension and high fluidity. This is achieved via a previously unrecognized mechanism in which interkinetic nuclear movements generate cell area dynamics that drive extensive cell rearrangements. Over time, the proliferation rate declines, effectively solidifying the tissue. Thus, unlike well-studied jamming transitions, the solidification we uncovered resembles a glass transition that depends on the dynamics of stresses generated by proliferation and differentiation. This new link between epithelial fluidity, interkinetic movements and cell cycle dynamics has implications for the precision of pattern formation and could be relevant to multiple developing tissues.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 20, 2022.
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Cell cycle dynamics controls fluidity of the developing mouse neuroepithelium
Laura Bocanegra-Moreno, Amrita Singh, Edouard Hannezo, Marcin Zagorski, Anna Kicheva
bioRxiv 2022.01.20.477048; doi: https://doi.org/10.1101/2022.01.20.477048
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Cell cycle dynamics controls fluidity of the developing mouse neuroepithelium
Laura Bocanegra-Moreno, Amrita Singh, Edouard Hannezo, Marcin Zagorski, Anna Kicheva
bioRxiv 2022.01.20.477048; doi: https://doi.org/10.1101/2022.01.20.477048

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