New Results
A chemical biology toolbox to investigate in-cell target engagement and specificity of PRMT5-inhibitors
View ORCID ProfileElisabeth M. Rothweiler, View ORCID ProfileJakub Stefaniak, View ORCID ProfileJennifer A. Ward, Catherine Rogers, Esra Balikci, View ORCID ProfileKilian V. M. Huber
doi: https://doi.org/10.1101/2022.01.20.477145
Elisabeth M. Rothweiler
1Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7FZ, UK
2Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7FZ, UK
Jakub Stefaniak
1Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7FZ, UK
2Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7FZ, UK
Jennifer A. Ward
1Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7FZ, UK
2Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7FZ, UK
Catherine Rogers
1Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7FZ, UK
2Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7FZ, UK
Esra Balikci
1Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7FZ, UK
2Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7FZ, UK
Kilian V. M. Huber
1Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7FZ, UK
2Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7FZ, UK
Posted January 27, 2022.
A chemical biology toolbox to investigate in-cell target engagement and specificity of PRMT5-inhibitors
Elisabeth M. Rothweiler, Jakub Stefaniak, Jennifer A. Ward, Catherine Rogers, Esra Balikci, Kilian V. M. Huber
bioRxiv 2022.01.20.477145; doi: https://doi.org/10.1101/2022.01.20.477145
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