Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Functional gradients in the human lateral prefrontal cortex revealed by a comprehensive coordinate-based meta-analysis

View ORCID ProfileMajd Abdallah, View ORCID ProfileGaston Zanitti, Valentin Iovene, View ORCID ProfileDemian Wassermann
doi: https://doi.org/10.1101/2022.01.21.477198
Majd Abdallah
1Team Parietal, Inria, CEA, Université Paris-Saclay, Palaiseau, 91120, France
2NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, 91190, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Majd Abdallah
  • For correspondence: majd.abdallah@inria.fr
Gaston Zanitti
1Team Parietal, Inria, CEA, Université Paris-Saclay, Palaiseau, 91120, France
2NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, 91190, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Gaston Zanitti
Valentin Iovene
1Team Parietal, Inria, CEA, Université Paris-Saclay, Palaiseau, 91120, France
2NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, 91190, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Demian Wassermann
1Team Parietal, Inria, CEA, Université Paris-Saclay, Palaiseau, 91120, France
2NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, 91190, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Demian Wassermann
  • For correspondence: majd.abdallah@inria.fr
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

The human lateral prefrontal cortex (LPFC) enables flexible goal-directed behavior. Yet, its organizing principles remain actively debated despite decades of research. Meta-analysis efforts to map the LPFC have either been restricted in scope or suffered from limited expressivity in meta-analysis tools. The latter short-coming hinders the complexity of questions that can be expressed in a meta-analysis and hence limits the specificity of structure-function associations. Here, we adopt NeuroLang, a novel approach to meta-analysis based on first-order probabilistic logic programming, to infer the organizing principles of the LPFC with greater specificity from 14,371 neuroimaging publications. Our results reveal a rostrocaudal and a dorsoventral gradient, respectively explaining the most and second-most variance in whole-brain meta-analytic connectivity in the LPFC. Moreover, we find a cross-study agreement on a spectrum of increasing abstraction from caudal to rostral LPFC both in specific network connectivity and structure-function associations that supports a domain-general role for the mid-LPFC. Furthermore, meta-analyzing inter-hemispheric asymmetries along the rostrocaudal gradient reveals specific associations with topics of language, memory, response inhibition, and error processing. Overall, we provide a comprehensive mapping of the organizing principles of task-dependent activity in the LPFC, grounding future hypothesis generation on a quantitative overview of past findings.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder has placed this preprint in the Public Domain. It is no longer restricted by copyright. Anyone can legally share, reuse, remix, or adapt this material for any purpose without crediting the original authors.
Back to top
PreviousNext
Posted January 23, 2022.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Functional gradients in the human lateral prefrontal cortex revealed by a comprehensive coordinate-based meta-analysis
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Functional gradients in the human lateral prefrontal cortex revealed by a comprehensive coordinate-based meta-analysis
Majd Abdallah, Gaston Zanitti, Valentin Iovene, Demian Wassermann
bioRxiv 2022.01.21.477198; doi: https://doi.org/10.1101/2022.01.21.477198
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Functional gradients in the human lateral prefrontal cortex revealed by a comprehensive coordinate-based meta-analysis
Majd Abdallah, Gaston Zanitti, Valentin Iovene, Demian Wassermann
bioRxiv 2022.01.21.477198; doi: https://doi.org/10.1101/2022.01.21.477198

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (3609)
  • Biochemistry (7585)
  • Bioengineering (5533)
  • Bioinformatics (20825)
  • Biophysics (10344)
  • Cancer Biology (7995)
  • Cell Biology (11653)
  • Clinical Trials (138)
  • Developmental Biology (6617)
  • Ecology (10224)
  • Epidemiology (2065)
  • Evolutionary Biology (13639)
  • Genetics (9557)
  • Genomics (12856)
  • Immunology (7930)
  • Microbiology (19568)
  • Molecular Biology (7675)
  • Neuroscience (42182)
  • Paleontology (308)
  • Pathology (1259)
  • Pharmacology and Toxicology (2208)
  • Physiology (3271)
  • Plant Biology (7058)
  • Scientific Communication and Education (1295)
  • Synthetic Biology (1953)
  • Systems Biology (5433)
  • Zoology (1119)