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A proxy measure of striatal dopamine predicts individual differences in temporal precision

View ORCID ProfileRenata Sadibolova, Luna Monaldi, View ORCID ProfileDevin B. Terhune
doi: https://doi.org/10.1101/2022.01.21.477273
Renata Sadibolova
Department of Psychology, Goldsmiths, University of London
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  • For correspondence: r.sadibolova@gold.ac.uk
Luna Monaldi
Department of Psychology, Goldsmiths, University of London
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Devin B. Terhune
Department of Psychology, Goldsmiths, University of London
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Abstract

The perception of time is characterized by pronounced variability across individuals, with implications for a diverse array of psychological functions. The neurocognitive sources of this variability are poorly understood but accumulating evidence suggests a role for inter-individual differences in striatal dopamine levels. Here we present a pre-registered study that tested the predictions that spontaneous eye blink rates, which provide a proxy measure of striatal dopamine availability, would be associated with aberrant interval timing (lower temporal precision or overestimation bias). Neurotypical adults (N=69) underwent resting state eye tracking and completed visual psychophysical interval timing and control tasks. Elevated spontaneous eye blink rates were associated with poorer temporal precision but not with inter-individual differences in perceived duration or performance on the control task. These results signify a role for striatal dopamine in variability in human time perception and can help explain deficient temporal precision in psychiatric populations characterized by elevated dopamine levels.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • https://osf.io/jxc3f

  • https://osf.io/fzdbv

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted January 21, 2022.
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A proxy measure of striatal dopamine predicts individual differences in temporal precision
Renata Sadibolova, Luna Monaldi, Devin B. Terhune
bioRxiv 2022.01.21.477273; doi: https://doi.org/10.1101/2022.01.21.477273
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A proxy measure of striatal dopamine predicts individual differences in temporal precision
Renata Sadibolova, Luna Monaldi, Devin B. Terhune
bioRxiv 2022.01.21.477273; doi: https://doi.org/10.1101/2022.01.21.477273

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