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Nasally-delivered interferon-λ protects mice against upper and lower respiratory tract infection of SARS-CoV-2 variants including Omicron
Zhenlu Chong, Courtney E. Karl, Peter J. Halfmann, Yoshihiro Kawaoka, Emma S. Winkler, Jinsheng Yu, View ORCID ProfileMichael S. Diamond
doi: https://doi.org/10.1101/2022.01.21.477296
Zhenlu Chong
1Department of Medicine, Washington University School of Medicine, St. Louis, St. Louis, MO, USA
Courtney E. Karl
1Department of Medicine, Washington University School of Medicine, St. Louis, St. Louis, MO, USA
2Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA
Peter J. Halfmann
3Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA
Yoshihiro Kawaoka
3Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA
4Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
5The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan
Emma S. Winkler
1Department of Medicine, Washington University School of Medicine, St. Louis, St. Louis, MO, USA
6Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, St. Louis, MO, USA
Jinsheng Yu
7Department of Genetics, Washington University School of Medicine, St. Louis, St. Louis, MO, USA
Michael S. Diamond
1Department of Medicine, Washington University School of Medicine, St. Louis, St. Louis, MO, USA
2Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA
6Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, St. Louis, MO, USA
8The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, St. Louis, MO, USA
Posted January 24, 2022.
Nasally-delivered interferon-λ protects mice against upper and lower respiratory tract infection of SARS-CoV-2 variants including Omicron
Zhenlu Chong, Courtney E. Karl, Peter J. Halfmann, Yoshihiro Kawaoka, Emma S. Winkler, Jinsheng Yu, Michael S. Diamond
bioRxiv 2022.01.21.477296; doi: https://doi.org/10.1101/2022.01.21.477296
Nasally-delivered interferon-λ protects mice against upper and lower respiratory tract infection of SARS-CoV-2 variants including Omicron
Zhenlu Chong, Courtney E. Karl, Peter J. Halfmann, Yoshihiro Kawaoka, Emma S. Winkler, Jinsheng Yu, Michael S. Diamond
bioRxiv 2022.01.21.477296; doi: https://doi.org/10.1101/2022.01.21.477296
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