New Results
Alteration of myocardial structure and function in RAF1-associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs
View ORCID ProfileSaeideh Nakhaei-Rad, View ORCID ProfileFarhad Bazgir, View ORCID ProfileJulia Dahlmann, View ORCID ProfileAlexandra Viktoria Busley, View ORCID ProfileMarcel Buchholzer, Fereshteh Haghighi, View ORCID ProfileAnne Schänzer, View ORCID ProfileAndreas Hahn, View ORCID ProfileSebastian Kötter, View ORCID ProfileDenny Schanze, View ORCID ProfileRuchika Anand, View ORCID ProfileFlorian Funk, Andrea Borchardt, Annette Vera Kronenbitter, View ORCID ProfileJürgen Scheller, View ORCID ProfileRoland P. Piekorz, View ORCID ProfileAndreas S. Reichert, Marianne Volleth, View ORCID ProfileMatthew J. Wolf, View ORCID ProfileIon Cristian Cirstea, View ORCID ProfileBruce D. Gelb, View ORCID ProfileMarco Tartaglia, View ORCID ProfileJoachim Schmitt, View ORCID ProfileMartina Krüger, Ingo Kutschka, View ORCID ProfileLukas Cyganek, View ORCID ProfileMartin Zenker, View ORCID ProfileGeorge Kensah, View ORCID ProfileMohammad R. Ahmadian
doi: https://doi.org/10.1101/2022.01.22.477319
Saeideh Nakhaei-Rad
1Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
16Saeideh Nakhaei-Rad, Stem Cell Biology and Regenerative Medicine Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran; Julia Dahlmann, Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiac, Thoracic-, Transplantation and Vascular Surgery, REBIRTH-Research Center for Translational and Regenerative Medicine, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover Medical School, 30625 Hannover, Germany. Marcel Buchholzer, Institute for Molecular Physiology, Heinrich Heine University Düsseldorf, Düsseldorf 40225, Germany
Farhad Bazgir
1Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Julia Dahlmann
2Institute of Human Genetics, University Hospital, Otto von Guericke-University, Magdeburg, Germany
3Clinic for Cardiothoracic and Vascular Surgery, University Medical Center, Göttingen, Germany
16Saeideh Nakhaei-Rad, Stem Cell Biology and Regenerative Medicine Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran; Julia Dahlmann, Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiac, Thoracic-, Transplantation and Vascular Surgery, REBIRTH-Research Center for Translational and Regenerative Medicine, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover Medical School, 30625 Hannover, Germany. Marcel Buchholzer, Institute for Molecular Physiology, Heinrich Heine University Düsseldorf, Düsseldorf 40225, Germany
Alexandra Viktoria Busley
4Stem Cell Unit, Clinic for Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany
5German Center for Cardiovascular Research (DZHK), partner site Göttingen, Germany
6Cluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells”, University of Göttingen, Germany
Marcel Buchholzer
1Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
16Saeideh Nakhaei-Rad, Stem Cell Biology and Regenerative Medicine Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran; Julia Dahlmann, Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiac, Thoracic-, Transplantation and Vascular Surgery, REBIRTH-Research Center for Translational and Regenerative Medicine, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover Medical School, 30625 Hannover, Germany. Marcel Buchholzer, Institute for Molecular Physiology, Heinrich Heine University Düsseldorf, Düsseldorf 40225, Germany
Fereshteh Haghighi
1Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
3Clinic for Cardiothoracic and Vascular Surgery, University Medical Center, Göttingen, Germany
5German Center for Cardiovascular Research (DZHK), partner site Göttingen, Germany
Anne Schänzer
7Institute of Neuropathology, Justus Liebig University Giessen, Giessen, Germany
Andreas Hahn
8Department of Child Neurology, Justus Liebig University Giessen, 35392 Giessen, Germany
Sebastian Kötter
9Institute of Cardiovascular Physiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Denny Schanze
2Institute of Human Genetics, University Hospital, Otto von Guericke-University, Magdeburg, Germany
Ruchika Anand
10Institute of Biochemistry and Molecular Biology I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Florian Funk
11Institute of Pharmacology and Clinical Pharmacology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Andrea Borchardt
10Institute of Biochemistry and Molecular Biology I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Annette Vera Kronenbitter
11Institute of Pharmacology and Clinical Pharmacology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Jürgen Scheller
1Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Roland P. Piekorz
1Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Andreas S. Reichert
10Institute of Biochemistry and Molecular Biology I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Marianne Volleth
2Institute of Human Genetics, University Hospital, Otto von Guericke-University, Magdeburg, Germany
Matthew J. Wolf
12Department of Medicine and Robert M. Berne Cardiovascular Research Center, University of Virginia, USA
Ion Cristian Cirstea
13Institute of Comparative Molecular Endocrinology, University of Ulm, Helmholtzstrasse 8/1, 89081 Ulm, Germany
Bruce D. Gelb
14Mindich Child Health and Development Institute and Departments of Pediatrics and Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Marco Tartaglia
15Genetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, IRCCS, 00146 Rome, Italy
Joachim Schmitt
11Institute of Pharmacology and Clinical Pharmacology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Martina Krüger
9Institute of Cardiovascular Physiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Ingo Kutschka
3Clinic for Cardiothoracic and Vascular Surgery, University Medical Center, Göttingen, Germany
5German Center for Cardiovascular Research (DZHK), partner site Göttingen, Germany
Lukas Cyganek
4Stem Cell Unit, Clinic for Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany
5German Center for Cardiovascular Research (DZHK), partner site Göttingen, Germany
6Cluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells”, University of Göttingen, Germany
Martin Zenker
2Institute of Human Genetics, University Hospital, Otto von Guericke-University, Magdeburg, Germany
George Kensah
3Clinic for Cardiothoracic and Vascular Surgery, University Medical Center, Göttingen, Germany
5German Center for Cardiovascular Research (DZHK), partner site Göttingen, Germany
Mohammad R. Ahmadian
1Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Posted January 23, 2022.
Alteration of myocardial structure and function in RAF1-associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs
Saeideh Nakhaei-Rad, Farhad Bazgir, Julia Dahlmann, Alexandra Viktoria Busley, Marcel Buchholzer, Fereshteh Haghighi, Anne Schänzer, Andreas Hahn, Sebastian Kötter, Denny Schanze, Ruchika Anand, Florian Funk, Andrea Borchardt, Annette Vera Kronenbitter, Jürgen Scheller, Roland P. Piekorz, Andreas S. Reichert, Marianne Volleth, Matthew J. Wolf, Ion Cristian Cirstea, Bruce D. Gelb, Marco Tartaglia, Joachim Schmitt, Martina Krüger, Ingo Kutschka, Lukas Cyganek, Martin Zenker, George Kensah, Mohammad R. Ahmadian
bioRxiv 2022.01.22.477319; doi: https://doi.org/10.1101/2022.01.22.477319
Alteration of myocardial structure and function in RAF1-associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs
Saeideh Nakhaei-Rad, Farhad Bazgir, Julia Dahlmann, Alexandra Viktoria Busley, Marcel Buchholzer, Fereshteh Haghighi, Anne Schänzer, Andreas Hahn, Sebastian Kötter, Denny Schanze, Ruchika Anand, Florian Funk, Andrea Borchardt, Annette Vera Kronenbitter, Jürgen Scheller, Roland P. Piekorz, Andreas S. Reichert, Marianne Volleth, Matthew J. Wolf, Ion Cristian Cirstea, Bruce D. Gelb, Marco Tartaglia, Joachim Schmitt, Martina Krüger, Ingo Kutschka, Lukas Cyganek, Martin Zenker, George Kensah, Mohammad R. Ahmadian
bioRxiv 2022.01.22.477319; doi: https://doi.org/10.1101/2022.01.22.477319
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