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Targeting Noradrenergic Neurons of the Locus Coeruleus: A Comparison of Model Systems and Strategies

Chantal Wissing, View ORCID ProfileMaxime Maheu, View ORCID ProfileSimon Wiegert, View ORCID ProfileAlexander Dieter
doi: https://doi.org/10.1101/2022.01.22.477348
Chantal Wissing
1Synaptic Wiring Lab, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Maxime Maheu
1Synaptic Wiring Lab, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
2Section Computational Cognitive Neuroscience, Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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  • ORCID record for Maxime Maheu
Simon Wiegert
1Synaptic Wiring Lab, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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  • For correspondence: simon.wiegert@zmnh.uni-hamburg.de
Alexander Dieter
1Synaptic Wiring Lab, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Abstract

The locus coeruleus (LC) noradrenergic system is involved in a plethora of physiological and pathophysiological processes. Refining our understanding of LC function largely relies on selective transgene expression in molecularly defined cells, enabling targeted manipulation and read-out of noradrenergic neurons. Here, we performed a side-by-side comparison of the most commonly used strategies and model systems enabling genetic access to the locus coeruleus. We report substantial differences among them both in terms of transgene expression efficacy, and in their molecular specificity. These findings are of critical importance for interpreting the results obtained from past experiments using the respective targeting strategies, as well as for the design of future studies.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted January 23, 2022.
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Targeting Noradrenergic Neurons of the Locus Coeruleus: A Comparison of Model Systems and Strategies
Chantal Wissing, Maxime Maheu, Simon Wiegert, Alexander Dieter
bioRxiv 2022.01.22.477348; doi: https://doi.org/10.1101/2022.01.22.477348
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Targeting Noradrenergic Neurons of the Locus Coeruleus: A Comparison of Model Systems and Strategies
Chantal Wissing, Maxime Maheu, Simon Wiegert, Alexander Dieter
bioRxiv 2022.01.22.477348; doi: https://doi.org/10.1101/2022.01.22.477348

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