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Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV-2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case
Lee Tatham, Anja Kipar, Joanne Sharp, Edyta Kijak, Joanne Herriott, View ORCID ProfileMegan Neary, Helen Box, Eduardo Gallardo Toledo, Anthony Valentijn, Helen Cox, Henry Pertinez, Paul Curley, Usman Arshad, Rajith KR Rajoli, Steve Rannard, James Stewart, View ORCID ProfileAndrew Owen
doi: https://doi.org/10.1101/2022.01.23.477397
Lee Tatham
1Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK
2Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, Liverpool, UK
Anja Kipar
3Laboratory for Animal Model Pathology, Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 268, 8057 Zurich, Switzerland
4Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK
Joanne Sharp
1Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK
2Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, Liverpool, UK
Edyta Kijak
1Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK
2Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, Liverpool, UK
Joanne Herriott
1Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK
2Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, Liverpool, UK
Megan Neary
1Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK
2Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, Liverpool, UK
Helen Box
1Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK
2Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, Liverpool, UK
Eduardo Gallardo Toledo
1Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK
2Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, Liverpool, UK
Anthony Valentijn
1Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK
2Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, Liverpool, UK
Helen Cox
1Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK
2Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, Liverpool, UK
Henry Pertinez
1Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK
2Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, Liverpool, UK
Paul Curley
1Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK
2Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, Liverpool, UK
Usman Arshad
1Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK
2Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, Liverpool, UK
Rajith KR Rajoli
1Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK
2Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, Liverpool, UK
Steve Rannard
2Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, Liverpool, UK
5Department of Chemistry, University of Liverpool, Liverpool, UK
James Stewart
4Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK
Andrew Owen
1Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK
2Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, Liverpool, UK
Article usage
Posted March 09, 2023.
Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV-2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case
Lee Tatham, Anja Kipar, Joanne Sharp, Edyta Kijak, Joanne Herriott, Megan Neary, Helen Box, Eduardo Gallardo Toledo, Anthony Valentijn, Helen Cox, Henry Pertinez, Paul Curley, Usman Arshad, Rajith KR Rajoli, Steve Rannard, James Stewart, Andrew Owen
bioRxiv 2022.01.23.477397; doi: https://doi.org/10.1101/2022.01.23.477397
Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV-2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case
Lee Tatham, Anja Kipar, Joanne Sharp, Edyta Kijak, Joanne Herriott, Megan Neary, Helen Box, Eduardo Gallardo Toledo, Anthony Valentijn, Helen Cox, Henry Pertinez, Paul Curley, Usman Arshad, Rajith KR Rajoli, Steve Rannard, James Stewart, Andrew Owen
bioRxiv 2022.01.23.477397; doi: https://doi.org/10.1101/2022.01.23.477397
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