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Bistable nerve conduction

Zhaoyang Zhang, Zhilin Qu
doi: https://doi.org/10.1101/2022.01.25.477744
Zhaoyang Zhang
1Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
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Zhilin Qu
1Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
2Department of Computational Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
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  • For correspondence: zqu@mednet.ucla.edu
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Abstract

The essence of the nerve system is to transmit information from and to different parts of the body in response to environmental changes. Here we show that a bistable conduction behavior can occur in the nerve system, which exhibits stimulus-dependent fast and slow conduction waves. The bistable behavior is caused by a positive feedback loop of the wavefront upstroke speed, mediated by the sodium channel inactivation properties, which is further potentiated by the calcium current. This provides a mechanism for the slow and fast conduction in the same nerve system observed experimentally. We show that the bistable conduction behavior is robust with respect to the experimentally determined activation thresholds of the known sodium and calcium channel families. The theoretical insights provide a generic mechanism for stimulus-dependent fast and slow conduction in the nerve system, which is applicable to conduction in other electrically excitable tissue, such as cardiac muscles.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted January 27, 2022.
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Bistable nerve conduction
Zhaoyang Zhang, Zhilin Qu
bioRxiv 2022.01.25.477744; doi: https://doi.org/10.1101/2022.01.25.477744
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Bistable nerve conduction
Zhaoyang Zhang, Zhilin Qu
bioRxiv 2022.01.25.477744; doi: https://doi.org/10.1101/2022.01.25.477744

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